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dc.contributor.authorYuksel, I. Temel
dc.contributor.authorAbali, R.
dc.contributor.authorYuksel, M. Aytac
dc.contributor.authorUnal, F.
dc.contributor.authorBoran, B.
dc.date.accessioned2021-03-03T15:08:34Z
dc.date.available2021-03-03T15:08:34Z
dc.date.issued2016
dc.identifier.citationUnal F., Yuksel M. A. , Boran B., Yuksel I. T. , Abali R., "The role of N-Acetylcysteine in preventing cyclophosphamide-induced gonadotoxicity: An experimental study in rats", JOURNAL OF OBSTETRICS AND GYNAECOLOGY, cilt.36, sa.3, ss.372-375, 2016
dc.identifier.issn0144-3615
dc.identifier.othervv_1032021
dc.identifier.otherav_3d63a2ba-02ec-4e6b-b7bf-3869d116a267
dc.identifier.urihttp://hdl.handle.net/20.500.12627/45158
dc.identifier.urihttps://doi.org/10.3109/01443615.2015.1065236
dc.description.abstractThis study assessed whether NAC could prevent cyclophosphamide (CY)-induced damage, by measuring the anti-Mullerian hormone (AMH) levels. Forty-eight Sprague-Dawley female rats were divided into four groups: CY + NAC, CY, NAC and control, each including 12 rats. There was no significant difference among the 24-h AMH values of the groups (p = 0.452), whereas a significant difference was found in terms of 72-h values (p = 0.003). Paired comparisons revealed no significant difference between CY and CY + NAC (p>0.699) and NAC (p = 0.065) groups regarding 72-h AMH values. However, AMH concentrations of the CY group at 72 hours were significantly lower than those of the control group (p = 0.015). AMH concentrations of the CY + NAC group at 72 hours were also significantly lower than those of the NAC group (p = 0.002) and the control group (p = 0.002). The AMH levels of CY and CY + NAC groups at 72 hours were significantly lower than those at 24 hours. The 24-h and 72-h AMH levels in the NAC and control groups were similar. In the present study, a single dose of NAC failed to prevent the cytotoxic effects of CY.
dc.language.isoeng
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectCerrahi Tıp Bilimleri
dc.subjectKadın Hastalıkları ve Doğum
dc.subjectKADIN HASTALIKLARI & DOĞUM
dc.titleThe role of N-Acetylcysteine in preventing cyclophosphamide-induced gonadotoxicity: An experimental study in rats
dc.typeMakale
dc.relation.journalJOURNAL OF OBSTETRICS AND GYNAECOLOGY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume36
dc.identifier.issue3
dc.identifier.startpage372
dc.identifier.endpage375
dc.contributor.firstauthorID231834


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