THE EFFECTS OF ANTIDEPRESSANT DRUGS ON POLYMORPHONUCLEAR LEUKOCYTE FUNCTIONS AND LEVELS OF FOLIC ACID, VITAMIN B-12, ZINC AND COPPER IN MAJOR DEPRESSION

Abstract

Objective: Today it is known that frequently used antineoplastic agents, analgesics and antibiotics affect the immune system cells and can modify polymorphonuclear leukocyte (PMN) functions such as phagocytosis, lymphocyte proliferation and production of various cytokines. In this study we investigated the effect of antidepresssant drugs on PMN functions, serum folic acid, vitamin B-12, zinc, copper levels and hematological parameters in the patients with major depression (MD).