SCLEROSING HEMANGIOMA OF THE LUNG CLINICOPATHOLOGIC AND IMMUNOHISTOCHEMICAL FEATURES

Abstract

The aim of this study was to demonstrate the immunohistochemical profile of sclerosing hemangioma of the lung(SHL) as well as to analyse its clinicopathological features. Immunohistochemical analysis could be peroformed in 3 cases for antibodies against TTF-1, surfactant protein-B, NSE, Chromogranin A, synaptophsin, CD31, CD34, estrogen and progesteron receptors, cytokeratin 7 EMA, p53 and Ki-57. Positive immunoreactivity for EMA in both cells of SHL supports the epithelial origin of this tunor. Also, immunopositivity for TTF-1 (in both cells), cytokeratin 7 (in surface cells) and surfactant protein B (in surface cells) leads to pneumoctytic differentiation of tumor cells. Positivity for progersterone receptor antibody, although it was detected to be local, may be associated with the feamale predominancy of SHL. No evidence of a malignant phenotype was found by Ki-67 and p53 similar with literature. The results of our study were discussed and compared with literature.