Polymorphisms of the DNA Repair Genes XPD and XRCC1 and the Risk of Age-Related Macular Degeneration
Date
2010Author
Seven, Mehmet
Guven, Gulgun S.
Guven, Mehmet
Gorgun, Ebru
ÜNAL, MUSTAFA
Yenerel, Melda
Tatlipinar, Sinan
Yuksel, Adnan
Batar, Bahadir
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PURPOSE. Oxidative stress seems to be an important factor in the development of age-related macular degeneration (AMD). The role of DNA repair mechanisms has also received attention recently in AMD pathogenesis. This case-control study was conducted to determine the frequency of polymorphisms in two DNA repair enzyme genes, xeroderma pigmentosum complementation group D (XPD), codons 312 and 751, and x-ray cross-complementing group 1 (XRCC1), codons 194 and 399, in patients with AMD and in disease-free control subjects.
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