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dc.contributor.authorASOGLU, Oktar
dc.contributor.authorOzmen, Vahit
dc.contributor.authorMUDUN, Ayşe
dc.contributor.authorCABIOGLU, Neslihan
dc.contributor.authorKARANLIK, Hasan
dc.contributor.authorTUZLALI, S
dc.contributor.authorKECER, Mustafa
dc.contributor.authorIGCI, Abdullah
dc.date.accessioned2021-03-03T15:50:37Z
dc.date.available2021-03-03T15:50:37Z
dc.date.issued2006
dc.identifier.citationOzmen V., KARANLIK H., CABIOGLU N., IGCI A., KECER M., ASOGLU O., TUZLALI S., MUDUN A., "Factors predicting the sentinel and non-sentinel lymph node metastases in breast cancer", BREAST CANCER RESEARCH AND TREATMENT, cilt.95, sa.1, ss.1-6, 2006
dc.identifier.issn0167-6806
dc.identifier.otherav_411c73e8-a19f-4f16-8edd-8e983779a423
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/47504
dc.identifier.urihttps://doi.org/10.1007/s10549-005-9007-9
dc.description.abstractThe sentinel lymph node (SLN) is the only focus of axillary metastasis in a significant proportion of patients. In this single institutional study, clinicopathologic characteristics were investigated to determine the factors predicting the status of a SLN biopsy and the metastatic involvement of non-SLNs. Data were retrospectively reveiwed for 400 consecutive patients with clinical T1/T2 N0 breast cancer who underwent a SLN biopsy including axillary and/or internal mammary lymph nodes. The SLNs were evaluated by using the new AJCC staging criteria following multiple sectioning and immunohistochemical (IHC) analyses of nodes. The SLN contained metastases in 148 patients (38.5%) including 18 patients (12.2%) with micrometastases ( 0.2 cm). Five patients had isolated tumor cells detected by IHC (<= 0.2 mm, N-0i). Patients with tumor size more than 2 cm (T1, 29.8% versus T2, 51.6%; OR=2.31, 95% CI, 1.50-3.56) and lymphovascular invasion (LVI-, 30.3% versus LVI+, 51.3%; OR=2.07, 95% CI, 1.34-3.19) were more likely to have positive SLNs in both univariate and multivariate analyses. Among patients with a positive SLN biopsy, those with T2 tumors (versus T1; 63.1% versus 36.9; OR=2.93, 95% CI, 1.43-6.04), macrometastases in SLNs (versus micrometastases; 88.9% versus 11.1%; OR=8.83; 95% CI, 1.82-42.87) and extracapsular node extension (versus without extracapsular node extension; 65.4% versus 34.6%; OR, 2.23; 95% CI, 1.05-4.72) were more likely to have non-SLN metastases in both univariate and multivarite analyses. These results indicate that clinicopathologic factors might be helpful to select patients who were less likely to have negative SLN or non-SLNs. However, additional factors are still needed to be identified to omit surgical axillary staging.
dc.language.isoeng
dc.subjectOnkoloji
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectONKOLOJİ
dc.titleFactors predicting the sentinel and non-sentinel lymph node metastases in breast cancer
dc.typeMakale
dc.relation.journalBREAST CANCER RESEARCH AND TREATMENT
dc.contributor.department, ,
dc.identifier.volume95
dc.identifier.issue1
dc.identifier.startpage1
dc.identifier.endpage6
dc.contributor.firstauthorID16420


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