dc.contributor.author | Naesens, Lieve | |
dc.contributor.author | Goktas, Fusun | |
dc.contributor.author | Vanderlinden, Evelien | |
dc.contributor.author | Cesur, Zafer | |
dc.contributor.author | Cesur, Nesrin | |
dc.contributor.author | Ozbil, Mehmet | |
dc.date.accessioned | 2021-03-03T16:35:06Z | |
dc.date.available | 2021-03-03T16:35:06Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Goktas F., Ozbil M., Cesur N., Vanderlinden E., Naesens L., Cesur Z., "Novel N-(1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide derivatives as potent and selective influenza virus fusion inhibitors", ARCHIV DER PHARMAZIE, cilt.352, sa.11, 2019 | |
dc.identifier.issn | 0365-6233 | |
dc.identifier.other | av_45053a60-8ff4-45d4-b086-620e5d7455ff | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/50068 | |
dc.identifier.uri | https://doi.org/10.1002/ardp.201900028 | |
dc.description.abstract | Hemagglutinin is the surface protein of the influenza virus that mediates both binding and penetration of the virus into host cells. We here report on the synthesis and structure-activity relationship of some novel N-(1-thia-4-azaspiro[4.5]decan-4-yl)-carboxamide compounds carrying the 5-chloro-2-methoxybenzamide structure, designed as influenza virus fusion inhibitors. The carboxamides (1a-h, 2a-h) have a similar backbone structure as the fusion inhibitors that we reported on previously. Compounds 2b and 2d displayed inhibitory activity against influenza A/H3N2 virus replication (average antiviral EC50: 2.1 mu M for 2b and 3.4 mu M for 2d). Data obtained in the hemolysis inhibition assay supported that these compounds act as inhibitors of the influenza virus hemagglutinin-mediated fusion process. | |
dc.language.iso | eng | |
dc.subject | Eczacılık | |
dc.subject | Temel Eczacılık Bilimleri | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Biyokimya | |
dc.subject | Alkoloidler | |
dc.subject | Temel Bilimler | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Farmakoloji ve Toksikoloji | |
dc.subject | FARMAKOLOJİ VE ECZACILIK | |
dc.subject | KİMYA, MULTİDİSİPLİNER | |
dc.subject | Temel Bilimler (SCI) | |
dc.subject | Kimya | |
dc.subject | KİMYA, TIP | |
dc.title | Novel N-(1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide derivatives as potent and selective influenza virus fusion inhibitors | |
dc.type | Makale | |
dc.relation.journal | ARCHIV DER PHARMAZIE | |
dc.contributor.department | İstanbul Arel Üniversitesi , , | |
dc.identifier.volume | 352 | |
dc.identifier.issue | 11 | |
dc.contributor.firstauthorID | 267548 | |