Atezolizumab with or without chemotherapy in metastatic urothelial cancer (IMvigor130): a multicentre, randomised, placebo-controlled phase 3 trial

Tarih
2020
Yazar
De Giorgi, Ugo
Galsky, Matthew D.
Arranz Arija, Jose Angel
Bamias, Aristotelis
Davis, Ian D.
De Santis, Maria
Kikuchi, Eiji
Garcia-del-Muro, Xavier
Mencinger, Marina
Izumi, Kouji
Panni, Stefano
GÜMÜŞ, MAHMUT
ÖZGÜROĞLU, Mustafa
Kalebasty, Arash Rezazadeh
Park, Se Hoon
Alekseev, Boris
Schutz, Fabio A.
Li, Jian-Ri
Ye, Dingwei
Vogelzang, Nicholas J.
Bernhard, Sandrine
Tayama, Darren
Mariathasan, Sanjeev
Mecke, Almut
Thastrom, AnnChristine
Grande, Enrique
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Özet
Background Atezolizumab can induce sustained responses in metastatic urothelial carcinoma. We report the results of IMvigor130, a phase 3 trial that compared atezolizumab with or without platinum-based chemotherapy versus placebo plus platinum-based chemotherapy in first-line metastatic urothelial carcinoma.
Bağlantı
http://hdl.handle.net/20.500.12627/5056
https://doi.org/10.1016/s0140-6736(20)30230-0
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