Show simple item record

dc.contributor.authorAydiner, A
dc.contributor.authorTopuz, E
dc.contributor.authorAytekin, Y
dc.date.accessioned2021-03-03T16:46:35Z
dc.date.available2021-03-03T16:46:35Z
dc.date.issued1997
dc.identifier.citationAydiner A., Aytekin Y., Topuz E., "Effects of cisplatin on testicular tissue and the Leydig cell-pituitary axis", ONCOLOGY, cilt.54, sa.1, ss.74-78, 1997
dc.identifier.issn0030-2414
dc.identifier.otherav_46145697-ca44-4975-9e60-dde5d77d4738
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/50739
dc.identifier.urihttps://doi.org/10.1159/000227665
dc.description.abstractThe mechanisms responsible for the rapid increases in levels of gonadotropin and steroid hormones upon administration of cisplatin to rats are not clearly understood. In the present study, the morphologic effects of cisplatin on the testis and the relationship of these changes to serum hormone levels were studied in adult rats. Upon administration of a single dose (5 mg/kg) of cisplatin, the levels of testosterone in the peripheral blood decreased and the level of luteinizing hormone (LH) increased. After 3 days, significant damage to the germinal epithelium became detectable by morphologic examination. In Leydig and Sertoli cells, dilatation of the endoplasmic reticulum, structural changes in mitochondria and an increase in the numbers of inclusion bodies were detected. Although blood-testis barriers between Sertoli cells were normal, the relationship between germinal cells and the relationship between germinal cells and Sertoli cells were distorted. It is concluded that damage to Leydig cells and withdrawal of the controlling effects of the germinal epithelium on the LH-Leydig cell axis could explain the changes in serum hormone levels.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectOnkoloji
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectONKOLOJİ
dc.titleEffects of cisplatin on testicular tissue and the Leydig cell-pituitary axis
dc.typeMakale
dc.relation.journalONCOLOGY
dc.contributor.department, ,
dc.identifier.volume54
dc.identifier.issue1
dc.identifier.startpage74
dc.identifier.endpage78
dc.contributor.firstauthorID118296


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record