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dc.contributor.authorKavak, A
dc.contributor.authorBaykal, Can
dc.contributor.authorOzkayaBayazit, Esen
dc.date.accessioned2021-03-03T16:53:11Z
dc.date.available2021-03-03T16:53:11Z
dc.date.issued1997
dc.identifier.citationOzkayaBayazit E., Baykal C., Kavak A., "[Local DMSO treatment of macular and papular amyloidosis].", Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, cilt.48, sa.1, ss.31-7, 1997
dc.identifier.issn0017-8470
dc.identifier.otherav_46c74385-84b6-46ef-9bce-b73a56301197
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/51160
dc.identifier.urihttps://doi.org/10.1007/s001050050543
dc.description.abstractMacular amyloidosis (MA) and lichen amyloidosus (LA) a re the two major variants of the primary cutaneous amyloidoses which present with severe and therapy resistent itching. Various therapeutic modalities such as antihistamines, intralesional injection or topical application of corticosteroids, etretinate, UVB irradiation and dermo-abrasion have been employed with variable success. Recently, in a few case reports authors have observed encouraging beneficial clinical effects by using topical dimethyl sulphoxide (DMSO). In our study 10 patients with either MA or IA or biphasic amyloidosis were treated with a 50% solution of DMSO in water. 9 of them showed marked clinical improvement at the end of 6-20 weeks of treatment. Degranulation and depletion of the mast cells by DMSO is the most probable explanation for the rapid improvement of itching beginning within the first week of therapy. Remarkable flattening of the lichenoid papules which was obtained within 11 weeks of treatment is interpreted as a result of the improvement of itching and the related scratch effect. Histological examination after treatment revealed no disappearance of amyloid deposits in the papillary dermis. In the follow-up period relapses of itching and papules were observed. Therefore further studies are needed to find out the optimal procedure of therapy.
dc.language.isoeng
dc.subjectDermatoloji
dc.subjectDahili Tıp Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectDERMATOLOJİ
dc.title[Local DMSO treatment of macular and papular amyloidosis].
dc.typeMakale
dc.relation.journalDer Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
dc.contributor.department, ,
dc.identifier.volume48
dc.identifier.issue1
dc.identifier.startpage31
dc.identifier.endpage7
dc.contributor.firstauthorID118290


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