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dc.contributor.authorKoca, Sevim Baykal
dc.contributor.authorTalu, Canan Kelten
dc.contributor.authorLeblebici, Cem
dc.contributor.authorOzturk, Tulin Kilicaslan
dc.contributor.authorGucin, Zuhal
dc.contributor.authorHacihasanoglu, Ezgi
dc.date.accessioned2021-03-03T16:53:21Z
dc.date.available2021-03-03T16:53:21Z
dc.identifier.citationTalu C. K. , Leblebici C., Ozturk T. K. , Hacihasanoglu E., Koca S. B. , Gucin Z., "Primary breast carcinomas with neuroendocrine features: Clinicopathological features and analysis of tumor growth patterns in 36 cases", ANNALS OF DIAGNOSTIC PATHOLOGY, cilt.34, ss.122-130, 2018
dc.identifier.issn1092-9134
dc.identifier.otherav_46cfb682-e0b9-44bb-8ec0-d1b971d0ac6e
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/51171
dc.identifier.urihttps://doi.org/10.1016/j.anndiagpath.2018.03.010
dc.description.abstractPrimary breast carcinoma with neuroendocrine features (NEBC) is an uncommon tumor. In the classification of WHO 2012, these tumors were categorized as: 1- neuroendocrine tumor, well-differentiated; 2- neuroendocrine carcinoma, poorly differentiated/small cell carcinoma; and 3- invasive breast carcinoma with neuroendocrine differentiation. In this study, we reviewed NEBC except poorly differentiated/small cell carcinoma variant in order to define the morphological growth patterns and cytonuclear details of these tumors. All breast surgical excision materials between 2007 and 2016 were re-evaluated in terms of neuroendocrine differentiation. Thirty-six cases showing positive staining for synaptophysin and/or chromogranin A in >= 50% of tumor cells were included in the study. All cases were female with a mean age of 67.4. Mean tumor diameter was 26 mm. Multifocality was noted in 5 cases. Grossly, they were mostly infiltrative mass lesions. T stages, identified in 34 cases, were as follows: 13 cases with pTl; 19 pT2 and 2 pT3. We described schematically 4 types of patterns depending on predominant growth pattern, except one case: 1) Large-sized solid cohesive groups (6 cases), 2) Small- to medium-sized solid cohesive groups with trabeculae/ribbons and glandular structures (6 cases), 3) Mixed growth patterns (20 cases), 4) Invasive tumor with prominent extracellular and/or intracellular mucin (3 cases). The tumor cells were mostly polygonal-oval with eosinophilic/eosinophilic-granular cytoplasm. The nuclei of tumor cells were mostly round to oval with evenly distributed chromatin. Only 5 cases showed high grade nuclear and histological features. Molecular subtypes of the cases were as follows: 33 luminal A, 2 luminal B, and 1 triple negative. NEBC should come to mind when a tumor display one of the morphological patterns described above, composed of monotonous cells with mild to moderate nuclear pleomorphism and abundant eosinophilic/eosinophilic granular or clear cytoplasm, especially in elderly patients.
dc.language.isoeng
dc.subjectBiyokimya
dc.subjectCerrahi Tıp Bilimleri
dc.subjectPatoloji
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectPATOLOJİ
dc.subjectBiyoloji ve Biyokimya
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.titlePrimary breast carcinomas with neuroendocrine features: Clinicopathological features and analysis of tumor growth patterns in 36 cases
dc.typeMakale
dc.relation.journalANNALS OF DIAGNOSTIC PATHOLOGY
dc.contributor.departmentUniv Hlth Sci , ,
dc.identifier.volume34
dc.identifier.startpage122
dc.identifier.endpage130
dc.contributor.firstauthorID253486


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