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dc.contributor.authorKayali, Refik
dc.contributor.authorKiziler, Ali Riza
dc.contributor.authorCakatay, Ufuk
dc.contributor.authorAydemir, Birsen
dc.date.accessioned2021-03-03T17:29:42Z
dc.date.available2021-03-03T17:29:42Z
dc.date.issued2007
dc.identifier.citationKayali R., Cakatay U., Kiziler A. R. , Aydemir B., "Effect of alpha-lipoic acid supplementation on trace element levels in serum and in postmitotic tissue in aged rats", MEDICINAL CHEMISTRY, cilt.3, sa.3, ss.297-300, 2007
dc.identifier.issn1573-4064
dc.identifier.otherav_4a03aca7-17d5-437e-b0d1-efa62fa13cda
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/53188
dc.identifier.urihttps://doi.org/10.2174/157340607780620590
dc.description.abstractRedistribution of redox-active divalent metal ions (e.g. copper, zinc, and iron) in postmitotic tissues of lipoic acid supplemented aging rats has been proposed to contribute to metal-catalyzed protein oxidation. DL-alpha lipoic acid (LA) (100 mg/kg body wt/day) was administered intraperitoneally to the Sprague-Dawley rats for 14 days. Serum copper levels lowered in the aged rats with LA supplementation compared to the rats without LA supplementation. On the other hand, serum zinc and iron levels increased in the aged rats with LA supplementation compared to the rats without LA supplementation. Copper levels of the postmitotic tissues were not changed in the aged rats with LA supplementation compared to the controls. The heart zinc levels detected in LA supplemented rats were significantly lower than controls. Similarly, the iron levels of the heart were found to be significantly lower in LA supplemented rats when compared to control rats. LA supplementation did not affect brain and muscle iron levels. The brain and muscle zinc levels remained the same in both group of rats. Based on the findings of our study, we have concluded that LA may exhibit prooxidant effect depending on the altered trace element homeostasis. Therefore, our results emphasize the importance of monitoring the dose of LA supplementation, duration of treatment and its potential harmful effects in the postmitotic tissues of aged rats.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectTemel Bilimler (SCI)
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectBiyokimya
dc.subjectTemel Bilimler
dc.subjectKİMYA, TIP
dc.subjectKimya
dc.titleEffect of alpha-lipoic acid supplementation on trace element levels in serum and in postmitotic tissue in aged rats
dc.typeMakale
dc.relation.journalMEDICINAL CHEMISTRY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume3
dc.identifier.issue3
dc.identifier.startpage297
dc.identifier.endpage300
dc.contributor.firstauthorID181052


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