dc.contributor.author | Erbil, Y. | |
dc.contributor.author | Abaci, N. | |
dc.contributor.author | Erginel-Unaltuna, Nihan | |
dc.contributor.author | Oflaz, H. | |
dc.contributor.author | Ozbey, N. Colak | |
dc.contributor.author | Ekmekci, A. | |
dc.contributor.author | Agayev, A. | |
dc.contributor.author | Aksakal, N. | |
dc.date.accessioned | 2021-03-03T17:30:25Z | |
dc.date.available | 2021-03-03T17:30:25Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Ekmekci A., Abaci N., Ozbey N. C. , Agayev A., Aksakal N., Oflaz H., Erginel-Unaltuna N., Erbil Y., "Endothelial function and endothelial nitric oxide synthase intron 4a/b polymorphism in primary hyperparathyroidism", JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, cilt.32, sa.7, ss.611-616, 2009 | |
dc.identifier.issn | 0391-4097 | |
dc.identifier.other | av_4a15b0aa-af21-4c53-b75c-67bb13e9384d | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/53236 | |
dc.identifier.uri | https://doi.org/10.1007/bf03346518 | |
dc.description.abstract | Background and aim: Patients with symptomatic primary hyperparathyroidism (pHT) have increased cardiovascular morbidity and mortality. Endothelial nitric oxide synthase (eNOS) intron 4a/b polymorphism is associated with coronary artery disease and hypertension in various populations. Our aim is to evaluate endothelial function in patients with pHT during pre-operative hypercalcemic and postoperative normocalcemic periods and to determine whether intron 4a/b polymorphism of eNOS gene influences endothelial function. Subjects and Methods: Forty patients with pHT (age 48.48 +/- 11.64 yr) were examined pre-operatively and re-examined 5.8 +/- 1.9 months after parathyroidectomy. Forty-three healthy subjects (age 47.13 +/- 8.14 yr) were served as control group. Endothelial function was determined by flow-mediated dilation of brachial artery (FMD). eNOS4a/b polymorphism was detected by polymerase chain reaction. Results: FMD was significantly lower in patients pre-operatively compared with controls (8.48 +/- 1.78% vs 19.49 +/- 2.34%, p2.47 mmol/l) and PTH concentrations (>7.75 pmol/l) were significant independent predictors of lower FMD (<16.7%). ENOS4a/b polymorphism did not enter in this model. Conclusion: Impaired endothelial function in patients with pHT improves after successful parathyroid surgery. No compelling data are evident to suggest that eNOS4a/b polymorphism modifies the endothelial function in patients with pHT. (J. Endocrinol. Invest. 32: 611-616, 2009) (C) 2009, Editrice Kurtis | |
dc.language.iso | eng | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Endokrinoloji ve Metabolizma Hastalıkları | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | İç Hastalıkları | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | ENDOKRİNOLOJİ VE METABOLİZMA | |
dc.title | Endothelial function and endothelial nitric oxide synthase intron 4a/b polymorphism in primary hyperparathyroidism | |
dc.type | Makale | |
dc.relation.journal | JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 32 | |
dc.identifier.issue | 7 | |
dc.identifier.startpage | 611 | |
dc.identifier.endpage | 616 | |
dc.contributor.firstauthorID | 28313 | |