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dc.contributor.authorBasaran-Kucukgergin, C
dc.contributor.authorSeckin, S
dc.contributor.authorUysal, M
dc.date.accessioned2021-03-03T17:48:58Z
dc.date.available2021-03-03T17:48:58Z
dc.date.issued1999
dc.identifier.citationSeckin S., Basaran-Kucukgergin C., Uysal M., "Effect of acute and chronic administration of sodium valproate on lipid peroxidation and antioxidant system in rat liver", PHARMACOLOGY & TOXICOLOGY, cilt.85, sa.6, ss.294-298, 1999
dc.identifier.issn0901-9928
dc.identifier.otherav_4b9ccac6-5ac5-4578-9521-a05631c8bdf9
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/54252
dc.identifier.urihttps://doi.org/10.1111/j.1600-0773.1999.tb02025.x
dc.description.abstractChanges in glutathione and lipid peroxide levels as well as in the activities of superoxide dismutase, glutathione peroxidase, catalase and glutathione-S-transferase have been studied in rats after acute and chronic sodium valproate treatments. Glutathione levels were decreased only after acute sodium valproate treatment. Neither acute nor chronic treatment influenced lipid peroxidation but induced glutathione-S-transferase activity significantly. On the other hand, no alterations in glutathione peroxidase and superoxide dismutase activities were found, except slight induction of catalase activity after acute administration of sodium valproate. These results indicate that sodium valproate treatment did not induce oxidative stress in the liver.
dc.language.isoeng
dc.subjectFarmasötik Toksikoloji
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectEczacılık
dc.subjectMeslek Bilimleri
dc.subjectTemel Eczacılık Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTOKSİKOLOJİ
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.titleEffect of acute and chronic administration of sodium valproate on lipid peroxidation and antioxidant system in rat liver
dc.typeMakale
dc.relation.journalPHARMACOLOGY & TOXICOLOGY
dc.contributor.department, ,
dc.identifier.volume85
dc.identifier.issue6
dc.identifier.startpage294
dc.identifier.endpage298
dc.contributor.firstauthorID124316


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