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dc.contributor.authorIkikarakayali, G.
dc.contributor.authorCinar, Suzan
dc.contributor.authorErdem, A. P.
dc.contributor.authorErdem, M. A.
dc.contributor.authorGurol, A. O.
dc.contributor.authorSuzergoz, F.
dc.contributor.authorSepet, E.
dc.date.accessioned2021-03-03T18:04:18Z
dc.date.available2021-03-03T18:04:18Z
dc.date.issued2015
dc.identifier.citationSuzergoz F., Sepet E., Erdem A. P. , Cinar S., Ikikarakayali G., Erdem M. A. , Gurol A. O. , "Activity of dental pulp cells in semisolid 3D cultures initiated by transforming growth factor-beta 1 and bone morphogenetic protein 2, 4", CELLULAR AND MOLECULAR BIOLOGY, cilt.61, sa.5, ss.45-48, 2015
dc.identifier.issn0145-5680
dc.identifier.othervv_1032021
dc.identifier.otherav_4d0640ca-e71c-4011-b1a5-8af1bfea5414
dc.identifier.urihttp://hdl.handle.net/20.500.12627/55127
dc.description.abstractThe intention of this study was to investigate the effect of modified 3D culture conditions on dental pulp cells (DPCs). DPCs were isolated from extracted primary molar, premolar, and wisdom teeth. Tooth samples were divided into three groups as control group; plated into methyl cellulose medium without any supplementation, growth factor (GF) group; supplemented with bone morphogenetic proteins (BMP2, BMP4), transforming growth factor-beta 1 (TGF-beta 1) and growth factor+conditioned medium (GF+CM) group; supplemented with both growth factors and pulp conditioned medium. The DPCs were tested for colony forming ability, proliferation capacity and morphology. The highest colony forming ability was detected in the GF and GF+CM groups of DPCs isolated from wisdom teeth. The proliferation capacity was higher in GF+CM group of DPCs isolated from primary molars, and in GF and GF+CM groups of DPCs isolated from wisdom teeth. Scanning electron microscope (SEM) observation of the wisdom teeth samples showed cell-cell interactions in the GF and GF+CM groups. Our results indicate that growth factors and pulp conditioned medium in methyl cellulose culture created proper environment to follow the behavior of dental cells three-dimensionally.
dc.language.isoeng
dc.subjectHistoloji-Embriyoloji
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectSağlık Bilimleri
dc.subjectTemel Tıp Bilimleri
dc.subjectTıp
dc.subjectHÜCRE BİYOLOJİSİ
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleActivity of dental pulp cells in semisolid 3D cultures initiated by transforming growth factor-beta 1 and bone morphogenetic protein 2, 4
dc.typeMakale
dc.relation.journalCELLULAR AND MOLECULAR BIOLOGY
dc.contributor.departmentHarran Üniversitesi , ,
dc.identifier.volume61
dc.identifier.issue5
dc.identifier.startpage45
dc.identifier.endpage48
dc.contributor.firstauthorID219554


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