dc.contributor.author | Savage, Paul B. | |
dc.contributor.author | Mataraci-Kara, Emel | |
dc.contributor.author | Ozbek-Celik, Berna | |
dc.contributor.author | Damar-Celik, Damla | |
dc.date.accessioned | 2021-03-03T18:06:17Z | |
dc.date.available | 2021-03-03T18:06:17Z | |
dc.identifier.citation | Damar-Celik D., Mataraci-Kara E., Savage P. B. , Ozbek-Celik B., "Antibacterial and antibiofilm activities of ceragenins againstAchromobacterspecies isolated from cystic fibrosis patients", JOURNAL OF CHEMOTHERAPY, 2020 | |
dc.identifier.issn | 1120-009X | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_4d400e6a-e4cd-41b9-bfba-89fb06758a6f | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/55262 | |
dc.identifier.uri | https://doi.org/10.1080/1120009x.2020.1819702 | |
dc.description.abstract | Achromobacter species, which are recognized as emerging pathogens isolated from patients with cystic fibrosis, are capable of forming biofilm in the respiratory tract in patients and innate multidrug resistance to antimicrobials. CSAs are cationic salt derivatives that mimic the activity of antimicrobial peptides and exhibit antimicrobial activity against bacteria. In this study, the in vitro activities of various ceragenins against Achromobacter-species biofilms were investigated comparatively with a conventional antibiotic (meropenem). Biofilm-formation inhibition and biofilm-adhesion inhibition were investigated on five strong biofilm-producing strains. The lowest MIC(50)result was obtained with CSA-13. All of the tested CSAs showed significant biofilm inhibitory activity in the manner of a time- and concentration-dependent effect. To the best of our knowledge, this is the first article to evaluate the antibacterial and antibiofilm activities of tested CSAs against Achromobacter species. | |
dc.language.iso | eng | |
dc.subject | Biyoloji ve Biyokimya | |
dc.subject | FARMAKOLOJİ VE ECZACILIK | |
dc.subject | Farmakoloji ve Toksikoloji | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Temel Tıp Bilimleri | |
dc.subject | Biyokimya | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | İç Hastalıkları | |
dc.subject | Onkoloji | |
dc.subject | Cerrahi Tıp Bilimleri | |
dc.subject | Patoloji | |
dc.subject | Eczacılık | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Temel Bilimler | |
dc.subject | Temel Eczacılık Bilimleri | |
dc.subject | PATOLOJİ | |
dc.subject | İmmünoloji | |
dc.subject | BULAŞICI HASTALIKLAR | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | ONKOLOJİ | |
dc.title | Antibacterial and antibiofilm activities of ceragenins againstAchromobacterspecies isolated from cystic fibrosis patients | |
dc.type | Makale | |
dc.relation.journal | JOURNAL OF CHEMOTHERAPY | |
dc.contributor.department | İstanbul Teknik Üniversitesi , , | |
dc.contributor.firstauthorID | 2286239 | |