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dc.contributor.authorKuruca, Serap
dc.contributor.authorTUNCER, Safa
dc.contributor.authorTEKÇE, NESLİHAN
dc.contributor.authorDEMİRCİ, Mustafa
dc.contributor.authorCetin-Aktas, Esin
dc.contributor.authorSismanoglu, Soner
dc.contributor.authorSchweikl, Helmut
dc.contributor.authorOzen-Eroglu, Gunes
dc.date.accessioned2021-03-02T19:27:25Z
dc.date.available2021-03-02T19:27:25Z
dc.date.issued2020
dc.identifier.citationSismanoglu S., DEMİRCİ M., Schweikl H., Ozen-Eroglu G., Cetin-Aktas E., Kuruca S., TUNCER S., TEKÇE N., "Cytotoxic effects of different self-adhesive resin cements: Cell viability and induction of apoptosis.", The journal of advanced prosthodontics, cilt.12, sa.2, ss.89-99, 2020
dc.identifier.issn2005-7806
dc.identifier.otherav_1e1470c7-e0f6-4c72-bcef-4e734b3ee62b
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/5598
dc.identifier.urihttps://doi.org/10.4047/jap.2020.12.2.89
dc.description.abstractPURPOSE. The effects of four different self-adhesive resin cement materials on cell viability and apoptosis after direct and indirect exposure were evaluated using different cell culture techniques. MATERIALS AND METHODS. Self-adhesive cements were applied to NIH/3T3 mouse fibroblasts by the extract test method, cell culture inserts, and dentin barrier test method. After exposure periods of 24 h and 72 h, the cytotoxicity of these self-adhesive materials was evaluated using the MTT assay (viability) and the Annexin-V-FITC/P1 staining (apoptosis). RESULTS. The lowest cell viability was found in cells exposed to BeautiCem SA for 24 h in the extract test method. Cell viability was reduced to 70.6% compared to negative controls. After the 72 h exposure period, viability rate of cell cultures exposed to BeautiCem SA decreased more than 2- fold (29.5%) while cells exposed to RelyX U200 showed the highest viability rate of 71.4%. In the dentin barrier test method, BeautiCem SA induced the highest number of cells in apoptosis after a 24 h exposure (4.1%). Panavia SA Cement Plus was the material that caused the lowest number of cells in apoptosis (1.5%). CONCLUSION. The used self-adhesive cements have showed different cytotoxic effects based on the evaluation method. As exposure time increased, the materials showed more cytotoxic and apoptotic effects. BeautiCem SA caused significantly more severe cytotoxic and apoptotic effects than other cements tested. Moreover, cements other than BeautiCem SA have caused necrotic cell death rather than apoptotic cell death.
dc.language.isoeng
dc.subjectKlinik Tıp (MED)
dc.subjectSağlık Bilimleri
dc.subjectDİŞ HEKİMLİĞİ, ORAL CERRAHİ VE TIP
dc.subjectKlinik Tıp
dc.subjectTıp
dc.subjectDiş Hekimliği
dc.titleCytotoxic effects of different self-adhesive resin cements: Cell viability and induction of apoptosis.
dc.typeMakale
dc.relation.journalThe journal of advanced prosthodontics
dc.contributor.departmentAltınbaş Üniversitesi , ,
dc.identifier.volume12
dc.identifier.issue2
dc.identifier.startpage89
dc.identifier.endpage99
dc.contributor.firstauthorID2194883


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