dc.contributor.author | Uysal, Mujdat | |
dc.contributor.author | Vural, Pervin | |
dc.contributor.author | Yorulmaz, Eda | |
dc.contributor.author | Yildiz, Zeynep | |
dc.contributor.author | Dogru-Abbasoglu, Semra | |
dc.contributor.author | Okan, Gokhan | |
dc.contributor.author | Gokdemir, Gonca | |
dc.date.accessioned | 2021-03-03T18:19:16Z | |
dc.date.available | 2021-03-03T18:19:16Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Okan G., Yildiz Z., Gokdemir G., Yorulmaz E., Vural P., Dogru-Abbasoglu S., Uysal M., "G-231A and G+70C Polymorphisms of Endothelin Receptor Type-A Gene could Affect the Psoriasis Area and Severity Index Score and Endothelin 1 Levels", INDIAN JOURNAL OF DERMATOLOGY, cilt.60, sa.2, 2015 | |
dc.identifier.issn | 0019-5154 | |
dc.identifier.other | av_4e6b4b07-021a-438b-a51e-e1c4362baa51 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/56012 | |
dc.identifier.uri | https://doi.org/10.4103/0019-5154.152561 | |
dc.description.abstract | Background: The etiopathogenesis of psoriasis has not been clearly elucidated although the role of chronic inflammation, imbalance between pro- and anti-inflammatory cytokines, and many immunological events have been established. Endothelin 1 (EDN1) and endothelin receptor type-A (EDNRA) are implicated in the inflammatory process. The relationships between EDN1 and EDNRA polymorphisms with several diseases have been found. Aims and Objectives: This study examined the possible association of EDN1 (G5665T and T-1370G) and EDNRA (G-231A and G + 70C) single nucleotide polymorphisms (SNPs) with the occurence of psoriasis, and evaluated the relationship between genotypes and clinical/laboratory manifestation of psoriasis. Materials and Methods : We analyzed genotype and allele distributions of the above-mentioned polymorphisms in 151 patients with psoriasis and 152 healthy controls by real-time PCR combined with melting curve analysis. Results : We did not find significant differences in the genotype and allele distributions of EDN1 T-1370G, EDNRA G-231A, and EDNRA G+70C polymorphisms between patients with psoriasis and healthy controls. Psoriasis area and severity index (PASI) score of EDNRA-231 polymorphic A allele carrying subjects (AA and AA + AG) was higher than that of wild homozygotes (P = 0.044 and P = 0.027, respectively). In addition, EDN1 levels in EDNRA+70 polymorphic C allele carriers (CC + CG) were elevated when compared with GG genotype; however, the difference was at borderline significance (P = 0.05). Conclusion: Although there were no associations between studied polymorphisms and psoriasis susceptibility, the PASI score and EDN1 levels seem to be affected by EDNRA G-231A and G + 70C polymorphisms. | |
dc.language.iso | eng | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Dermatoloji | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | DERMATOLOJİ | |
dc.title | G-231A and G+70C Polymorphisms of Endothelin Receptor Type-A Gene could Affect the Psoriasis Area and Severity Index Score and Endothelin 1 Levels | |
dc.type | Makale | |
dc.relation.journal | INDIAN JOURNAL OF DERMATOLOGY | |
dc.contributor.department | Medical Park Hospitals Group , , | |
dc.identifier.volume | 60 | |
dc.identifier.issue | 2 | |
dc.contributor.firstauthorID | 221352 | |