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dc.contributor.authorMULAZIMOGLU, MEHMET
dc.contributor.authorYILMAZ, Alev
dc.contributor.authorGedikbasi, Asuman
dc.contributor.authorOZPACACI, TEVFIK
dc.contributor.authorHATIPOGLU, SAMI
dc.contributor.authorSevketoglu, Esra
dc.contributor.authorKaryagar, Savas
dc.contributor.authorKiyak, Aysel
dc.contributor.authorAydogan, Gonul
dc.date.accessioned2021-03-03T18:25:29Z
dc.date.available2021-03-03T18:25:29Z
dc.date.issued2009
dc.identifier.citationYILMAZ A., Sevketoglu E., Gedikbasi A., Karyagar S., Kiyak A., MULAZIMOGLU M., Aydogan G., OZPACACI T., HATIPOGLU S., "Early prediction of urinary tract infection with urinary neutrophil gelatinase associated lipocalin", PEDIATRIC NEPHROLOGY, cilt.24, sa.12, ss.2387-2392, 2009
dc.identifier.issn0931-041X
dc.identifier.othervv_1032021
dc.identifier.otherav_4ef20469-6063-4e61-9752-79e2f557e322
dc.identifier.urihttp://hdl.handle.net/20.500.12627/56358
dc.identifier.urihttps://doi.org/10.1007/s00467-009-1279-6
dc.description.abstractNeutrophil gelatinase associated lipocalin (NGAL) is a protein identified in human neutrophil granules. The aim of the study was to assess whether urine level of NGAL (uNGAL) could represent a novel, reliable marker of urinary tract infection (UTI) and to determine the optimal cutoff level for uNGAL to predict UTI in children. Sixty patients with symptomatic UTI and 29 healthy controls were enrolled the study. Urine NGAL was measured by enzyme-linked immunosorbent assay. A dimercaptosuccinic acid (DMSA) radionuclide scan was performed within 7 days in the patients with UTI in an attempt to distinguish pyelonephritis from cystitis. Mean uNGAL level was significantly higher in the UTI group than in the controls (91.02 ng/ml vs 14.29 ng/ml, p = 0.0001) and using a cutoff 20 ng/ml for uNGAL for diagnosis of UTI, sensitivity, and specificity were 97% and 76%, respectively [area under the curve (AUC): 0.979]. Mean uNGAL/creatinine ratio (uNGAL/Cr) was also significantly higher in the UTI group [201.81 ng/mg creatinine (Cr) vs 18.08 ng/mg Cr; p = 0.0001], and using a cutoff 30 ng/mg Cr for uNGAL/Cr for diagnosis of UTI, sensitivity and specificity were 98% and 76%, respectively (AUC: 0.992). In conclusion, both uNGAL and uNGAL/Cr can be used as a novel, sensitive marker for early prediction of UTI in the absence of acute kidney injury and chronic kidney disease, and the optimal cutoff value for prediction of UTI is lower than the values determined for acute kidney injury. Further investigations with larger patient groups are required to confirm our results.
dc.language.isoeng
dc.subjectİç Hastalıkları
dc.subjectNefroloji
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectTıp
dc.subjectÜROLOJİ VE NEFROLOJİ
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectPEDİATRİ
dc.subjectÇocuk Sağlığı ve Hastalıkları
dc.titleEarly prediction of urinary tract infection with urinary neutrophil gelatinase associated lipocalin
dc.typeMakale
dc.relation.journalPEDIATRIC NEPHROLOGY
dc.contributor.departmentBakirkoy Dr. Sadi Konuk Research & Training Hospital , ,
dc.identifier.volume24
dc.identifier.issue12
dc.identifier.startpage2387
dc.identifier.endpage2392
dc.contributor.firstauthorID727419


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