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dc.contributor.authorSarac, A. Sezai
dc.contributor.authorDÖŞLER, Sibel
dc.contributor.authorKök, Fatma Neşe
dc.contributor.authorGÜNGÖR, Sevgi
dc.contributor.authorERDAL, Meryem Sedef
dc.contributor.authorEsenturk, Imren
dc.contributor.authorGumrukcu, Selin
dc.contributor.authorSert, Ayse Buse Ozdabak
dc.date.accessioned2021-03-02T19:29:52Z
dc.date.available2021-03-02T19:29:52Z
dc.identifier.citationEsenturk I., Gumrukcu S., Sert A. B. O. , Kök F. N. , DÖŞLER S., GÜNGÖR S., ERDAL M. S. , Sarac A. S. , "Silk-fibroin-containing nanofibers for topical sertaconazole delivery: preparation, characterization, and antifungal activity", INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, 2020
dc.identifier.issn0091-4037
dc.identifier.othervv_1032021
dc.identifier.otherav_437ca1ae-eba2-4a9e-b491-bb603110e0d2
dc.identifier.urihttp://hdl.handle.net/20.500.12627/5651
dc.identifier.urihttps://doi.org/10.1080/00914037.2020.1740992
dc.description.abstractPolyurethane/polyvinylpyrrolidone/silk nanofibers were prepared by electrospinning. Highly lipophilic antifungal drug sertaconazole nitrate was incorporated into the nanofibers, and drug release profiles were compared with polyurethane/polyvinylpyrrolidone nanofiber. Nanofibers were characterized in terms of morphology, polymer-polymer and drug-polymer compatibility, loading efficiency, surface roughness profile, and hydrophilicity by scanning electron microscopy, Fourier transform infrared spectroscopy, atomic force microscopy, optical tensiometer and high-performance liquid chromatography. In vitro release data revealed that nanofibers fabricated with silk fibroin either as polymer blend or coating material showed drug release in sustained manner. Activity and biocompatibility study analysis data proved that all sertaconazole incorporated nanofiber formulations were fungistatic against Candida albicans and had good biocompatibility, which could be considered as potential topical drug delivery systems used in the treatment of fungal infections as a scaffold applied topically.
dc.language.isoeng
dc.subjectPolimer Karakterizasyonu
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectTemel Bilimler (SCI)
dc.subjectFizikokimya
dc.subjectKimya
dc.subjectPOLİMER BİLİMİ
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectMalzeme Bilimi
dc.subjectMALZEME BİLİMİ, BİYOMATERYAL
dc.titleSilk-fibroin-containing nanofibers for topical sertaconazole delivery: preparation, characterization, and antifungal activity
dc.typeMakale
dc.relation.journalINTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
dc.contributor.departmentUniv Hlth Sci Turkey , ,
dc.contributor.firstauthorID838109


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