Show simple item record

dc.contributor.authorKAILANI, Baraah
dc.contributor.authorBener, Abdulbari
dc.contributor.authorDWEIK, Manar
dc.contributor.authorABU-FARA, Mohammed
dc.contributor.authorNABULSI, Rinad
dc.contributor.authorAWIDI, Abdalla
dc.contributor.authorSALEH, Akram
dc.date.accessioned2021-03-03T18:40:20Z
dc.date.available2021-03-03T18:40:20Z
dc.date.issued2011
dc.identifier.citationAWIDI A., SALEH A., DWEIK M., KAILANI B., ABU-FARA M., NABULSI R., Bener A., "Measurement of platelet reactivity of patients with cardiovascular disease on-treatment with acetyl salicylic acid: a prospective study", HEART AND VESSELS, cilt.26, sa.5, ss.516-522, 2011
dc.identifier.issn0910-8327
dc.identifier.otherav_50629aa2-3ee8-45fd-a93d-254184006209
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/57240
dc.identifier.urihttps://doi.org/10.1007/s00380-010-0086-0
dc.description.abstractAcetyl salicylic acid (ASA) and clopidogrel are extensively used in the prevention of cardiovascular disease. However, the responsiveness to ASA treatment may vary among individuals. This study was conducted to investigate the profile and prevalence of ASA resistance in cardiac patients. From August 2007 to August 2008, a total of 282 cardiac patients were enrolled. Two study groups were identified: patients taking 100 mg ASA daily but without clopidogrel, and patients taking both 100 mg ASA and 75 mg clopidogrel daily. Platelet function was determined with the Multiplate analyzer to determine platelet responsiveness. Salicylate blood level was measured for all patients on ASA. Seventy-three patients (26%) were determined to be nonresponsive to ASA, and 45 patients (16%) were partially responsive, whereas 164 patients (58.2%) were responsive to ASA. Myocardial infarction and coronary obstruction were both strongly associated with ASA nonresponsiveness (p < 0.001). ASA resistance occurred more in female patients (p = 0.002). The salicylate blood level was found to be low in ASA-resistant patients (35.33 +/- 50.22 mg/l) and higher in sensitive patients (54.26 +/- 18.7 mg/l; p < 0.001). Quantitative assessment of platelet functions is predictive of ASA treatment failure in individual patients. Dual antiplatelet treatment with clopidogrel and ASA was found to have greater inhibitory effects on platelet aggregation than either agent alone. Non-adherence may be a significant mediator of poor outcome.
dc.language.isoeng
dc.subjectDahili Tıp Bilimleri
dc.subjectKardiyoloji
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectPERİFERAL VASKÜLER HASTALIĞI
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectCARDIAC ve CARDIOVASCULAR SİSTEMLER
dc.titleMeasurement of platelet reactivity of patients with cardiovascular disease on-treatment with acetyl salicylic acid: a prospective study
dc.typeMakale
dc.relation.journalHEART AND VESSELS
dc.contributor.departmentUniversity of Jordan , ,
dc.identifier.volume26
dc.identifier.issue5
dc.identifier.startpage516
dc.identifier.endpage522
dc.contributor.firstauthorID96319


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record