dc.contributor.author | Banks, William A. | |
dc.contributor.author | Deshaies, Yves | |
dc.contributor.author | Miller, David S. | |
dc.contributor.author | Bartness, Timothy J. | |
dc.contributor.author | Richard, Denis | |
dc.contributor.author | Festuccia, William T. | |
dc.contributor.author | Oztezcan, Serdar | |
dc.contributor.author | Laplante, Mathieu | |
dc.contributor.author | Berthiaume, Magalie | |
dc.contributor.author | Michel, Chantal | |
dc.contributor.author | Dohgu, Shinya | |
dc.contributor.author | Denis, Raphael G. | |
dc.contributor.author | Brito, Marcia N. | |
dc.contributor.author | Brito, Nilton A. | |
dc.date.accessioned | 2021-03-03T18:58:23Z | |
dc.date.available | 2021-03-03T18:58:23Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Festuccia W. T. , Oztezcan S., Laplante M., Berthiaume M., Michel C., Dohgu S., Denis R. G. , Brito M. N. , Brito N. A. , Miller D. S. , et al., "Peroxisome proliferator-activated receptor-gamma-mediated positive energy balance in the rat is associated with reduced sympathetic drive to adipose tissues and thyroid status", ENDOCRINOLOGY, cilt.149, sa.5, ss.2121-2130, 2008 | |
dc.identifier.issn | 0013-7227 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_51fe0c58-8a00-4668-951d-faf14dddf8ff | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/58256 | |
dc.identifier.uri | https://doi.org/10.1210/en.2007-1553 | |
dc.description.abstract | Peroxisome proliferator-activated receptor-gamma (PPAR gamma) activation up-regulates thermogenesis-related genes in rodent white and brown adipose tissues (WAT and BAT) without increasing whole-body energy expenditure. We tested here whether such dissociation is the result of a negative modulation of sympathetic activity to WAT and BAT and thyroid axis components by PPAR gamma activation. Administration of the PPAR gamma agonist rosiglitazone (15 mg/kg center dot d) for 7 d to male Sprague Dawley rats increased food intake (10%), feed efficiency (31%), weight gain (45%), spontaneous motor activity (60%), and BAT and WAT mass and reduced whole-body oxygen consumption. Consistent with an anabolic setting, rosiglitazone markedly reduced sympathetic activity to BAT and WAT(> 50%) and thyroid status as evidenced by reduced levels of plasma thyroid hormones (T-4 and T-3) and mRNA levels of BAT and liver T-3-generating enzymes iodothyronine type 2 (-40%) and type 1 (-32%) deiodinases, respectively. Rosiglitazone also decreased mRNA levels of the thyroid hormone receptor (THR) isoforms alpha 1 (-34%) and beta (-66%) in BAT and isoforms alpha 1 (-20%) and alpha 2 (-47%) in retroperitoneal WAT. These metabolic effects were associated with a reduction in mRNAlevels of the pro-energy expenditure peptides CRH and CART in specific hypothalamic nuclei. A direct central action of rosiglitazone is, however, unlikely based on its low brain uptake and lack of metabolic effects of intracerebroventricular administration. In conclusion, a reduction in BAT sympathetic activity and thyroid status appears to, at least partly, explain the PPAR gamma-induced reduction in energy expenditure and the fact that up-regulation of thermogenic gene expression does not translate into functional stimulation of whole-body thermogenesis in vivo. | |
dc.language.iso | eng | |
dc.subject | Sağlık Bilimleri | |
dc.subject | İç Hastalıkları | |
dc.subject | Endokrinoloji ve Metabolizma Hastalıkları | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | ENDOKRİNOLOJİ VE METABOLİZMA | |
dc.title | Peroxisome proliferator-activated receptor-gamma-mediated positive energy balance in the rat is associated with reduced sympathetic drive to adipose tissues and thyroid status | |
dc.type | Makale | |
dc.relation.journal | ENDOCRINOLOGY | |
dc.contributor.department | Université Laval , , | |
dc.identifier.volume | 149 | |
dc.identifier.issue | 5 | |
dc.identifier.startpage | 2121 | |
dc.identifier.endpage | 2130 | |
dc.contributor.firstauthorID | 187689 | |