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Cytosolic 5 '-nucleotidase III (NT5C3): gene sequence variation and functional genomics

dc.contributor.authorEckloff, Bruce W.
dc.contributor.authorWieben, Eric D.
dc.contributor.authorYee, Vivien C.
dc.contributor.authorWeinshilboum, Richard M.
dc.contributor.authorWang, Liewei
dc.contributor.authorAksoy, Pınar
dc.contributor.authorZhu, Min Jia
dc.contributor.authorKalari, Krishna R.
dc.contributor.authorMoon, Irene
dc.contributor.authorPelleymounter, Linda L.
dc.date.accessioned2021-03-03T19:03:14Z
dc.date.available2021-03-03T19:03:14Z
dc.date.issued2009
dc.identifier.citationAksoy P., Zhu M. J. , Kalari K. R. , Moon I., Pelleymounter L. L. , Eckloff B. W. , Wieben E. D. , Yee V. C. , Weinshilboum R. M. , Wang L., "Cytosolic 5 '-nucleotidase III (NT5C3): gene sequence variation and functional genomics", PHARMACOGENETICS AND GENOMICS, cilt.19, sa.8, ss.567-576, 2009
dc.identifier.issn1744-6872
dc.identifier.otherav_527a784b-a6d7-4047-9e13-836cacbbbd20
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/58549
dc.identifier.urihttps://doi.org/10.1097/fpc.0b013e32832c14b8
dc.description.abstractBackground 5'-Nucleotidases play a critical role in nucleotide pool balance and in the metabolism of nucleoside analogs such as gemcitabine and cytosine arabinoside (AraC). We previously performed an expression array association study with gemcitabine and AraC cytotoxicity using 197 human lymphoblastoid cell lines. One gene that was significantly associated with gemcitabine cytotoxicity was a nucleotidase family member, NT5C3. Very little is known with regard to the pharmacogenomics of this family of enzymes.
dc.language.isoeng
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOTEKNOLOJİ VE UYGULAMALI MİKROBİYOLOJİ
dc.subjectMikrobiyoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectGENETİK VE HAYAT
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectTıbbi Genetik
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectBiyoteknoloji
dc.subjectTemel Bilimler
dc.titleCytosolic 5 '-nucleotidase III (NT5C3): gene sequence variation and functional genomics
dc.typeMakale
dc.relation.journalPHARMACOGENETICS AND GENOMICS
dc.contributor.departmentMayo Clinic , ,
dc.identifier.volume19
dc.identifier.issue8
dc.identifier.startpage567
dc.identifier.endpage576
dc.contributor.firstauthorID2207035


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