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dc.contributor.authorTekkesin, Merva
dc.contributor.authorBingul, I.
dc.contributor.authorDogru-Abbasoglu, S.
dc.contributor.authorUysal, M.
dc.contributor.authorBasaran-Kucukgergin, C.
dc.contributor.authorOlgac, V.
dc.date.accessioned2021-03-03T19:09:39Z
dc.date.available2021-03-03T19:09:39Z
dc.date.issued2016
dc.identifier.citationBasaran-Kucukgergin C., Bingul I., Tekkesin M., Olgac V., Dogru-Abbasoglu S., Uysal M., "Effects of carnosine, taurine, and betaine pretreatments on diethylnitrosamine-induced oxidative stress and tissue injury in rat liver", TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.32, sa.8, ss.1405-1413, 2016
dc.identifier.issn0748-2337
dc.identifier.othervv_1032021
dc.identifier.otherav_5309c4ea-328e-4ab2-b283-37dc66f4e1d2
dc.identifier.urihttp://hdl.handle.net/20.500.12627/58905
dc.identifier.urihttps://doi.org/10.1177/0748233714563432
dc.description.abstractSeveral chemicals such as N-diethylnitrosamine (DEN) promote hepatocellular cancer in rodents and induce hepatocyte injury. DEN affects the initiation stage of carcinogenesis together with enhanced cell proliferation accompanied by hepatocellular necrosis. DEN-induced hepatocellular necrosis is reported to be related to enhanced generation of reactive oxygen species. Carnosine (CAR), taurine (TAU), and betaine (BET) are known to have powerful antioxidant properties. We aimed to investigate the effects of CAR, TAU, and BET pretreatments on DEN-induced oxidative stress and liver injury in male rats. Rats were given CAR (2 g L-1 in drinking water), TAU (2.5% in chow), and BET (2.5% in chow) for 6 weeks and DEN (200 mg kg(-1) intraperitoneally) was given 2 days before the end of this period. Serum alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and -glutamyl transferase activities were determined and a histopathologic evaluation was performed on the liver tissue. Oxidative stress was detected in the liver by measuring malondialdehyde, diene conjugate, protein carbonyl and nitrotyrosine levels, glutathione and glutathione peroxidase levels, and superoxide dismutase and glutathione transferase activities. Pretreatments with CAR, TAU, and BET decreased liver prooxidant status without remarkable changes in antioxidant parameters in DEN-treated rats. Pretreatments with TAU and BET, but not CAR, were also found to be effective to reduce liver damage in DEN-treated rats. In conclusion, TAU, BET, and possibly CAR may have an ameliorating effect on DEN-induced hepatic injury by reducing oxidative stress in rats.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectKAMU, ÇEVRE VE İŞ SAĞLIĞI
dc.subjectSosyal Bilimler Genel
dc.subjectSosyal Bilimler (SOC)
dc.subjectTOKSİKOLOJİ
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectMeslek Bilimleri
dc.subjectFarmasötik Toksikoloji
dc.subjectSosyal ve Beşeri Bilimler
dc.subjectSosyoloji
dc.subjectYaşam Bilimleri
dc.titleEffects of carnosine, taurine, and betaine pretreatments on diethylnitrosamine-induced oxidative stress and tissue injury in rat liver
dc.typeMakale
dc.relation.journalTOXICOLOGY AND INDUSTRIAL HEALTH
dc.contributor.departmentİstanbul Üniversitesi , Onkoloji Enstitüsü , Tümör Patolojisi
dc.identifier.volume32
dc.identifier.issue8
dc.identifier.startpage1405
dc.identifier.endpage1413
dc.contributor.firstauthorID233999


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