dc.contributor.author | Aboul-Enein, Hassan Y. | |
dc.contributor.author | Cesur, Nesrin | |
dc.contributor.author | Ozkirimli, Sumru | |
dc.date.accessioned | 2021-03-03T19:30:49Z | |
dc.date.available | 2021-03-03T19:30:49Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Ozkirimli S., Aboul-Enein H. Y. , Cesur N., "ENANTIOSELECTIVE QUANTIFICATION OF DOXYLAMINE IN HUMAN PLASMA BY HPLC", JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, cilt.34, sa.9, ss.671-678, 2011 | |
dc.identifier.issn | 1082-6076 | |
dc.identifier.other | av_54f64822-5e32-424d-8aa4-d70fb4dc6114 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/60097 | |
dc.identifier.uri | https://doi.org/10.1080/10826076.2011.560700 | |
dc.description.abstract | A high pressure liquid chromatography-diode array detector (HPLC-DAD) method using amylose tris(3,5-dimethylphenyl carbamate) chiral stationary phase (Chiralpak AD-H) is described for the determination of doxylamine enantiomers in human plasma. Doxylamine enantiomers were separated on a Chiralpak AD-H column using a mobile phase composed of n-hexane-2-propanol-diethylamine (98:2:0.025, v/v/v). Diphenhydramine was used as an internal Standard (IS). Doxylamine was extracted from plasma samples using dichloromethane:hexane (1:2v/v), which yielded high extraction yields (87%), satisfactory precision (RSD1.05%), and good selectivity. Linearity was found in the 8-40 mu g center dot mL-1 range with the limits of detection 0.13 mu g center dot mL-1. Doxylamine enantiomers were well separated with no interference from endogenous plasma constituents. The method developed, showed a good linearity, sensitivity, and repeatability. | |
dc.language.iso | eng | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Temel Tıp Bilimleri | |
dc.subject | Biyokimya | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Sitogenetik | |
dc.subject | Analitik Kimya | |
dc.subject | Temel Bilimler | |
dc.subject | BİYOKİMYA VE MOLEKÜLER BİYOLOJİ | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Temel Bilimler (SCI) | |
dc.subject | Kimya | |
dc.subject | KİMYA, ANALİTİK | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Biyoloji ve Biyokimya | |
dc.subject | BİYOKİMYASAL ARAŞTIRMA YÖNTEMLERİ | |
dc.title | ENANTIOSELECTIVE QUANTIFICATION OF DOXYLAMINE IN HUMAN PLASMA BY HPLC | |
dc.type | Makale | |
dc.relation.journal | JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | |
dc.contributor.department | National Research Centre (NRC) , , | |
dc.identifier.volume | 34 | |
dc.identifier.issue | 9 | |
dc.identifier.startpage | 671 | |
dc.identifier.endpage | 678 | |
dc.contributor.firstauthorID | 21341 | |