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dc.contributor.authorElicin, Olgun
dc.contributor.authorUzel, Omer Erol
dc.contributor.authorUzel, Esengul Kocak
dc.contributor.authorEkmekcioglu, Ozgul
dc.contributor.authorHalac, Metin
dc.date.accessioned2021-03-03T19:37:10Z
dc.date.available2021-03-03T19:37:10Z
dc.date.issued2013
dc.identifier.citationUzel E. K. , Ekmekcioglu O., Elicin O., Halac M., Uzel O. E. , "Is FDG -PET-CT A Valuable Tool in Prediction of Persistent Disease in Head and Neck Cancer", ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, cilt.14, sa.8, ss.4847-4851, 2013
dc.identifier.issn1513-7368
dc.identifier.otherav_55881f8b-ba1f-425f-af61-bc833e5efe16
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/60446
dc.identifier.urihttps://doi.org/10.7314/apjcp.2013.14.8.4847
dc.description.abstractObjectives: To evaluate accuracy of FDG-PET CT in prediction of persistent disease in head and neck cancer cases and to determine prognostic value of metabolic tumor response. Materials and Methods: Between 2009 and 2011, 46 patients with squamous cell carcinoma of head and neck receiving PET-CT were treated with definitive radiotherapy, with or without chemotherapy. There were 29 nasopharyngeal, 11 hypopharyngeal, 3 oropharyngeal and 3 laryngeal cancer patients, with a median age of 50.5 years (range 16-84), 32 males and 14 females. All patients were evaluated with PET-CT median 3-5 months (2.4-9.4) after completion of radiotherapy. Results: After a median 20 months of follow up, complete metabolic response was observed in 63% of patients. Suspicious residual uptake was present in 10.9% and residual metabolic uptake in 26.0% of patients. The overall sensitivity, specificity, positive predictive value and negative predictive value of FDG-PET-CT for detection of residual disease was 91% and 81%, 64% and 96% respectively. Two year LRC was 95% in complete responders while it was 34% in non-complete responders. Conclusions: FDG PET CT is a valuable tool for assessment of treatment response, especially in patients at high risk of local recurrence, and also as an indicator of prognosis. Definitely more precise criteria are required for assessment of response, there being no clear cut uptake value indicating residual disease. Futhermore, repair processes of normal tissue may consume glucose which appear as increased uptake in control FDG PET CT.
dc.language.isoeng
dc.subjectKlinik Tıp (MED)
dc.subjectOnkoloji
dc.subjectİç Hastalıkları
dc.subjectDahili Tıp Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectONKOLOJİ
dc.subjectKlinik Tıp
dc.titleIs FDG -PET-CT A Valuable Tool in Prediction of Persistent Disease in Head and Neck Cancer
dc.typeMakale
dc.relation.journalASIAN PACIFIC JOURNAL OF CANCER PREVENTION
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume14
dc.identifier.issue8
dc.identifier.startpage4847
dc.identifier.endpage4851
dc.contributor.firstauthorID207621


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