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dc.contributor.authorTutuncu, Mesude
dc.contributor.authorTutuncu, Melih
dc.date.accessioned2021-03-02T20:07:55Z
dc.date.available2021-03-02T20:07:55Z
dc.date.issued2020
dc.identifier.citationTutuncu M., Tutuncu M., "The effect of vitamin D on restless legs syndrome: prospective self-controlled case study", SLEEP AND BREATHING, cilt.24, sa.3, ss.1101-1106, 2020
dc.identifier.issn1520-9512
dc.identifier.othervv_1032021
dc.identifier.otherav_006b98b8-03e3-4df4-8eef-540fc055ffb2
dc.identifier.urihttp://hdl.handle.net/20.500.12627/6265
dc.identifier.urihttps://doi.org/10.1007/s11325-019-01984-3
dc.description.abstractPurpose To evaluate the effect of vitamin D on severity of restless legs syndrome in patients with idiopathic restless legs syndrome (RLS). Methods Patients with idiopathic RLS completed questionnaires including the International Restless Legs Severity Scale (IRLSS) and were evaluated for vitamin D deficiency. Patients with deficiency of vitamin D were treated with 50,000 units per week for 2 months. At the end of the 2 months, vitamin D levels were re-measured and disease severity was re-evaluated in patients who reached adequate vitamin D level. Subgroups of IRLSS questionnaire were also analyzed. Results Of 35 patients enrolled, 21 (60%) had vitamin D deficiency and received vitamin D therapy. In 2 patients, vitamin D levels did not rise to sufficient levels with supplementation and these 2 patients were excluded from analysis. The remaining 19 patients showed vitamin D levels increased from 13.2 +/- 4.0 to 42.8 +/- 9.6 ng/mL while IRLSS improved from 24.9 +/- 5.1 to 21.1 +/- 2.9 points (p <0.001). Selected subscores of the IRLSS were also improved including symptom severity (p <0.001), impact on sleep (p <0.001), symptom measures (p =0.002), and disease impact measures (p <0.001). There were trends toward improvement in subscores of frequency (p =0.11) and mood (p =0.051). Conclusions The findings suggest that vitamin D levels should be evaluated in patients with RLS and if vitamin D deficiency is revealed, consideration should be given to replacement therapy.u
dc.language.isoeng
dc.subjectNöroloji
dc.subjectDahili Tıp Bilimleri
dc.subjectGöğüs Hastalıkları ve Allerji
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectSOLUNUM SİSTEMİ
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectKLİNİK NEUROLOJİ
dc.titleThe effect of vitamin D on restless legs syndrome: prospective self-controlled case study
dc.typeMakale
dc.relation.journalSLEEP AND BREATHING
dc.contributor.departmentIstanbul Bakirkoy Mental Health & Neurology Training & Research Hospital , ,
dc.identifier.volume24
dc.identifier.issue3
dc.identifier.startpage1101
dc.identifier.endpage1106
dc.contributor.firstauthorID2274228


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