dc.contributor.author | Top, C | |
dc.contributor.author | Danaci, M | |
dc.contributor.author | Ozkan, S | |
dc.contributor.author | Cavuslu, S | |
dc.contributor.author | Oncul, O | |
dc.date.accessioned | 2021-03-03T20:22:45Z | |
dc.date.available | 2021-03-03T20:22:45Z | |
dc.date.issued | 2002 | |
dc.identifier.citation | Oncul O., Top C., Ozkan S., Cavuslu S., Danaci M., "Serum interleukin 2 levels in patients with rheumatoid arthritis and correlation with insulin sensitivity", JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.30, sa.4, ss.386-390, 2002 | |
dc.identifier.issn | 0300-0605 | |
dc.identifier.other | av_599ce996-cfe8-4157-9354-f339fbf81fcf | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/63039 | |
dc.identifier.uri | https://doi.org/10.1177/147323000203000404 | |
dc.description.abstract | Interleukin 2 (IL-2), a Th1 lymphocyte-derived cytokine, is thought to play an important role in the pathogenesis of type 2 diabetes and rheumatoid arthritis (RA). The aim of our study was to evaluate changes in serum IL-2 levels and their correlation with glucose metabolism abnormalities, such as insulin resistance, in patients with RA. Thirty-six subjects with varying degrees of disease activity and 20 healthy age-, sex- and body mass index-matched control individuals were evaluated. Patients with any causes of peripheral insulin resistance were excluded. After a 12-h overnight fast, fasting insulin levels, homeostatic model assessment-insulin resistance (HOMA-IR) estimated insulin sensitivity, and serum IL-2 levels were significantly higher in all patients with RA; than in the control individuals. Fasting insulin, HOMA-IR scores and IL-2 levels were correlated in the RA group. This study showed that patients with RA have altered IL-2 regulation, and that there was a significant correlation between serum IL-2 levels and insulin sensitivity. | |
dc.language.iso | eng | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Tıbbi Ekoloji ve Hidroklimatoloji | |
dc.subject | Eczacılık | |
dc.subject | Temel Eczacılık Bilimleri | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Temel Bilimler | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Farmakoloji ve Toksikoloji | |
dc.subject | FARMAKOLOJİ VE ECZACILIK | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | TIP, ARAŞTIRMA VE DENEYSEL | |
dc.title | Serum interleukin 2 levels in patients with rheumatoid arthritis and correlation with insulin sensitivity | |
dc.type | Makale | |
dc.relation.journal | JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | |
dc.contributor.department | İstanbul Üniversitesi , İstanbul Tıp Fakültesi , Dahili Tıp Bilimleri Bölümü | |
dc.identifier.volume | 30 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 386 | |
dc.identifier.endpage | 390 | |
dc.contributor.firstauthorID | 2209564 | |