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dc.contributor.authorDar, Kadriye Akgun
dc.contributor.authorKapucu, Ayşegül
dc.contributor.authorAlıustaoglu, Suheyla
dc.contributor.authorOz, Buge
dc.contributor.authorKadioglu, Pinar
dc.contributor.authorAkinci, Hakan
dc.contributor.authorCelik, Ozlem
dc.contributor.authorTutunculer, Banu
dc.contributor.authorSırın, Gozde
dc.contributor.authorGazioglu, Nurperi
dc.contributor.authorİnce, Haluk
dc.date.accessioned2021-03-03T20:25:42Z
dc.date.available2021-03-03T20:25:42Z
dc.identifier.citationAkinci H., Kapucu A., Dar K. A. , Celik O., Tutunculer B., Sırın G., Oz B., Gazioglu N., İnce H., Alıustaoglu S., et al., "Aromatase cytochrome P450 enzyme expression in prolactinomas and its relationship to tumor behavior", PITUITARY, cilt.16, ss.386-392, 2013
dc.identifier.issn1386-341X
dc.identifier.othervv_1032021
dc.identifier.otherav_59d3686a-5228-451d-a435-2b7494791f34
dc.identifier.urihttp://hdl.handle.net/20.500.12627/63184
dc.identifier.urihttps://doi.org/10.1007/s11102-012-0436-2
dc.description.abstractThe aim of the study was to evaluate the presence of aromatase cytochrome P450 enzyme (P450AROM) expression in normal pituitary tissues and tumor tissues of patients with prolactinoma and to examine the impact of the P450AROM expression on clinical outcome. Twenty-six consecutive human pituitary tissue samples were obtained from autopsies performed at the Institute of Forensic Medicine. Sixty-four patients who had an adenomectomy between 2000 and 2009 after prolactinoma diagnosis with histologically confirmed pituitary tumor tissues were retrospectively included in this study. The slices from the pituitary tissues were subjected to immunohistochemical staining for evaluation of P450AROM and estrogen receptor beta (ER beta) subunit. Immunohistochemistry results were compared according to age, gender, remission rate, resistance and invasion status of the patients. Higher than normal P450AROM expression was found in the pituitary tissues of the patients with prolactinoma (p < 0.001). P450AROM intensity had no relation to resistance or remission in patients with prolactinoma (p = 0.44, p = 0.45, respectively). The subgroup analysis showed that compared to males without invasive adenoma, males with invasive adenoma had higher P450AROM expression (p = 0.048). ER beta was found to have an impact on resistance (p = 0.049). This study shows that P450AROM expression is present in the pituitary tissues of patients with prolactinoma and that this presence could be important in development and tumor behavior of prolactinomas.
dc.language.isoeng
dc.subjectEndokrinoloji ve Metabolizma Hastalıkları
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectENDOKRİNOLOJİ VE METABOLİZMA
dc.titleAromatase cytochrome P450 enzyme expression in prolactinomas and its relationship to tumor behavior
dc.typeMakale
dc.relation.journalPITUITARY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume16
dc.identifier.startpage386
dc.identifier.endpage392
dc.contributor.firstauthorID1044975


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