dc.contributor.author | KOKOGLU, Emine Hakkı | |
dc.contributor.author | ULAKOGLU, Emine Gülruh | |
dc.date.accessioned | 2021-03-02T20:09:13Z | |
dc.date.available | 2021-03-02T20:09:13Z | |
dc.date.issued | 1991 | |
dc.identifier.citation | KOKOGLU E. H. , ULAKOGLU E. G. , "THE TRANSPORT OF VITAMIN-E IN PLASMA AND ITS CORRELATION TO PLASMA-LIPOPROTEINS IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS", DIABETES RESEARCH AND CLINICAL PRACTICE, cilt.14, sa.3, ss.175-181, 1991 | |
dc.identifier.issn | 0168-8227 | |
dc.identifier.other | av_008875fb-c900-417b-b044-6df18e4e3deb | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/6358 | |
dc.identifier.uri | https://doi.org/10.1016/0168-8227(91)90018-9 | |
dc.description.abstract | It is known that plasma low density lipoproteins (LDL) contain a great amount of vitamin E and that LDL enter cells via the specific receptor-mediated mechanism. In this study, we aimed to investigate the transport of alpha-tocopherol from plasma to tissues in subjects with non-insulin-dependent diabetes mellitus (NIDDM) with poor glycaemic control; and the relationships between alpha-tocopherol and plasma lipid and lipoprotein levels. alpha-Tocopherol determination was carried out by colorimetric assay according to the modified micromethod of Fabianek et al. The mean plasma alpha-tocopherol and (LDL + VLDL)-alpha-tocopherol levels increased significantly in the diabetic group as compared to control (P < 0.05 and P < 0.02), whereas the high density lipoprotein (HDL)-alpha-tocopherol level was significantly lower in the diabetic group than that in the controls (P < 0.05). Correlations between plasma alpha-tocopherol levels showed close positive relationships (r = 0.87, r = 0.75 and r = 0.78, respectively, P < 0.001). A strong positive correlation was also observed between alpha-tocopherol and the cholesterol content, either in the HDL or in the (LDL + VLDL) fractions (r = 0.75 and r = 0.77; P < 0.001). These findings indicate that there is a direct positive relationship between lipid and alpha-tocopherol concentrations. The increased level of alpha-tocopherol in the LDL + VLDL fraction and decreased level in HDL in these patients could be attributed to the impairment of the cholesterol uptake of the cells by the receptor mediated mechanism. | |
dc.language.iso | eng | |
dc.subject | İç Hastalıkları | |
dc.subject | Endokrinoloji ve Metabolizma Hastalıkları | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | ENDOKRİNOLOJİ VE METABOLİZMA | |
dc.title | THE TRANSPORT OF VITAMIN-E IN PLASMA AND ITS CORRELATION TO PLASMA-LIPOPROTEINS IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS | |
dc.type | Makale | |
dc.relation.journal | DIABETES RESEARCH AND CLINICAL PRACTICE | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 14 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 175 | |
dc.identifier.endpage | 181 | |
dc.contributor.firstauthorID | 4502 | |