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Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida beta-carbonic anhydrase enzyme

dc.contributor.authorGoektas, Fuesun
dc.contributor.authorKarali, Nilgün Lütfiye
dc.contributor.authorAngeli, Andrea
dc.contributor.authorSupuran, Claudiu T.
dc.contributor.authorEraslan Elma, Pinar
dc.contributor.authorAKDEMİR, ATİLLA
dc.date.accessioned2021-03-03T20:44:43Z
dc.date.available2021-03-03T20:44:43Z
dc.date.issued2019
dc.identifier.citationAKDEMİR A., Angeli A., Goektas F., Eraslan Elma P., Karali N. L. , Supuran C. T. , "Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida beta-carbonic anhydrase enzyme", JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.34, sa.1, ss.528-531, 2019
dc.identifier.issn1475-6366
dc.identifier.othervv_1032021
dc.identifier.otherav_5b8823c2-4aa0-4e04-85ba-127b77d0d6b0
dc.identifier.urihttp://hdl.handle.net/20.500.12627/64259
dc.identifier.urihttps://doi.org/10.1080/14756366.2018.1564045
dc.description.abstractInhibition of the beta-carbonic anhydrase (CA, EC 4.2.1.1) from pathogenic Candida glabrata (CgNce103) by 1H-indole-2,3-dione 3-[N-(4-sulfamoylphenyl)thiosemicarbazones] 4a-m was investigated. All the compounds were found to be potent inhibitors of CgNce103, with inhibition constants in the range of 6.4-63.9 nM. The 5,7-dichloro substituted derivative 4l showed the most effective inhibition (K-I of 6.4 nM) as well as the highest selectivity for inhibiting CgNce103 over the cytosolic human (h) isoforms hCA I and II. A possible binding interaction of compound 4l within the active site of CgNce103 has been proposed based on docking studies.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectBiyokimya
dc.subjectTemel Bilimler
dc.subjectTemel Bilimler (SCI)
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectKimya
dc.subjectKİMYA, TIP
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleNovel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida beta-carbonic anhydrase enzyme
dc.typeMakale
dc.relation.journalJOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
dc.contributor.departmentBezmiâlem Vakıf Üniversitesi , Eczacılık Fakültesi , Farmakoloji Anabilim Dalı
dc.identifier.volume34
dc.identifier.issue1
dc.identifier.startpage528
dc.identifier.endpage531
dc.contributor.firstauthorID260677


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