dc.contributor.author | Haznedaroglu, Ibrahim C. | |
dc.contributor.author | ÖZCEBE, OSMAN İLHAMİ | |
dc.contributor.author | Ozbek, Ugur | |
dc.contributor.author | Sayitoglu, Müge | |
dc.contributor.author | Hatirnaz Ng, Ozden | |
dc.contributor.author | Tatonyan, Suzin C. | |
dc.contributor.author | Uz, Burak | |
dc.contributor.author | Erbilgin, Yucel | |
dc.contributor.author | BÜYÜKAŞIK, YAHYA | |
dc.contributor.author | AKSU, SALİH | |
dc.contributor.author | SAYINALP, NİLGÜN | |
dc.contributor.author | GÖKER, HAKAN | |
dc.date.accessioned | 2021-03-04T08:45:46Z | |
dc.date.available | 2021-03-04T08:45:46Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Uz B., Tatonyan S. C. , Sayitoglu M., Erbilgin Y., Hatirnaz Ng O., BÜYÜKAŞIK Y., AKSU S., SAYINALP N., GÖKER H., ÖZCEBE O. İ. , et al., "Renin-Angiotensin System (RAS) Expressions in Myeloid Leukemic Cell Lines", UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI, cilt.23, sa.4, ss.264-268, 2013 | |
dc.identifier.issn | 1306-133X | |
dc.identifier.other | av_64e6cee7-1f9e-4a61-b2f1-bfb547cd7a8c | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/70184 | |
dc.identifier.uri | https://doi.org/10.4999/uhod.13014 | |
dc.description.abstract | The aim of this study is to search critical renin-angiotensin system (RAS) elements in myeloid leukemic cell lines. Human acute myeloid leukemia (AML) cell lines, KG-1 and HL-60, were cultured. We searched for the gene expression of the major RAS components in KG-1 and HL-60 cell lines by quantitative real-time polymerase chain reaction analysis (qRT-PCR). Angiotensin-converting enzyme I (ACE I) and ACE II mRNA expressions were detected in KG-1 AML cell line. Relative expression of ACE I was higher than ACE II expression in this myeloid leukemic cells. Likewise, RENIN, angiotensinogen (ANGTS), and ACE I mRNA expressions were detected in HL-60 promyelocytic cell line. Relative RENIN expression was the highest, whereas ACE I expression was the lowest in HL-60 neoplastic myeloid cells. These findings indicate that there is a biologically active local RAS in the hematopoietic system in normal and pathological states. | |
dc.language.iso | eng | |
dc.subject | Onkoloji | |
dc.subject | ONKOLOJİ | |
dc.subject | Klinik Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | İç Hastalıkları | |
dc.title | Renin-Angiotensin System (RAS) Expressions in Myeloid Leukemic Cell Lines | |
dc.type | Makale | |
dc.relation.journal | UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI | |
dc.contributor.department | Hacettepe Üniversitesi , , | |
dc.identifier.volume | 23 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 264 | |
dc.identifier.endpage | 268 | |
dc.contributor.firstauthorID | 362 | |