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dc.contributor.authorDalan, Altay Burak
dc.contributor.authorCimen, Arif
dc.contributor.authorPolat, Nihat
dc.contributor.authorToptas, Bahar
dc.contributor.authorBugra, Zehra
dc.contributor.authorYilmaz-Aydogan, Hulya
dc.contributor.authorIsbir, TURGAY
dc.date.accessioned2021-03-04T10:03:13Z
dc.date.available2021-03-04T10:03:13Z
dc.date.issued2013
dc.identifier.citationDalan A. B. , Toptas B., Bugra Z., Polat N., Yilmaz-Aydogan H., Cimen A., Isbir T., "The effects of endothelial lipase gene (LIPG) variants on inflammation marker levels and atherosclerosis development", MOLECULAR BIOLOGY REPORTS, cilt.40, sa.8, ss.5143-5149, 2013
dc.identifier.issn0301-4851
dc.identifier.otherav_6b47faa1-911f-4e95-adbf-e535ce177873
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/74193
dc.identifier.urihttps://doi.org/10.1007/s11033-013-2615-2
dc.description.abstractAtherosclerosis is a major pathological process related with several important adverse vascular events including coronary artery disease, stroke, and peripheral arterial disease. Endothelial lipase is an enzyme the activity of which affects all of lipoproteins, whereas HDL is the main substrate. The purpose of our study was to investigate the effects of endothelial lipase gene polymorphism and inflammation markers (CRP, IL-1 beta, IL-6, IL-8 and TNF-alpha) in the atherosclerosis. 104 patients with atherosclerosis and 76 healthy individuals were included in the study. LIPG -584C/T polymorphism gene polymorphisms were assessed with PCR-RFLP method. The serum CRP levels were measured by turbidimetric method using a biochemistry autoanalyzer, whereas serum IL-1 beta, IL-6, IL-8, TNF-alpha levels were determined by enzyme-linked immunosorbent assay. In this study, we found that the frequencies of TC genotype are more prevalent in patients than controls. We found a statistically significant difference of IL-6 levels between patient and control group. Our findings suggest that T allele might play a potential role in the susceptibility to atherogenesis in the Turkish population.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.titleThe effects of endothelial lipase gene (LIPG) variants on inflammation marker levels and atherosclerosis development
dc.typeMakale
dc.relation.journalMOLECULAR BIOLOGY REPORTS
dc.contributor.departmentYeditepe Üniversitesi , ,
dc.identifier.volume40
dc.identifier.issue8
dc.identifier.startpage5143
dc.identifier.endpage5149
dc.contributor.firstauthorID10450


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