Durability of sustained virologic response in chronic hepatitis C
Tarih
2013Yazar
Demir, Kadir
Cakaloglu, Yilmaz
Kaymakoglu, Sabahattin
Besisik, Fatih
Akyuz, Filiz
UYANIKOĞLU, AHMET
Danalioglu, Ahmet
Ermis, Fatih
Pinarbasi, Binnur
Üst veri
Tüm öğe kaydını gösterÖzet
Background/Aims: The aim of this study is to investigate the rate of sustained virologic response (SVR) in chronic hepatitis C patients receiving antiviral treatment. Methods: The files of patients with chronic hepatitis C treated with interferon ribavirin between 1995 and 2009 were reviewed retrospectively. Six months after the end of treatment, patients with negative hepatitis C virus (HCV)-RNA (<50 IU/mL, as determined by the polymerase chain reaction method) were enrolled in the study. Results: The mean age of 196 patients (89 males) was 46.13 +/- 11.10 years (range, 17 to 73 years). In biopsies, the mean stage was 1.50 +/- 0.94; histological activity index was 7.18 +/- 2.43. In total, 139 patients received pegylated interferon (IFN)+ribavirin, 21 patients received classical IFN+ribavirin, and 36 patients received IFN alone. The HCV genotypes of 138 patients were checked: 77.5% were genotype 1b, and 22.5% were other genotypes. After achievement of SVR, the median follow-up period was 33.5 months (range, 6 to 112 months), and in this period relapse was only detected in two patients (1.02%) at 18 and 48 months after treatment. Conclusions: In total, 98.9% of patients with SVR in chronic hepatitis C demonstrated truly durable responses over the long-term follow-up period of 3 years; relapsed patients had intermittent or low-grade viremia.
Bağlantı
http://hdl.handle.net/20.500.12627/74697https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84880302539&origin=inward
https://doi.org/10.5009/gnl.2013.7.4.458
Koleksiyonlar
- Makale [92796]