dc.contributor.author | See, Peter | |
dc.contributor.author | Zhang, Jinqiu | |
dc.contributor.author | Goh, Chi Ching | |
dc.contributor.author | Gül, Ahmet | |
dc.contributor.author | Hubert, Sandra | |
dc.contributor.author | Lee, Bernett | |
dc.contributor.author | Chen, Jinmiao | |
dc.contributor.author | Huber, Tara | |
dc.contributor.author | Ashihara, Eishi | |
dc.contributor.author | Garel, Sonia | |
dc.contributor.author | Pouladi, Mahmoud A. | |
dc.contributor.author | Ginhoux, Florent | |
dc.contributor.author | Low, Ivy | |
dc.contributor.author | Shadan, Nurhidaya Binte | |
dc.contributor.author | Lum, Josephine | |
dc.contributor.author | Wei, Tay Seok | |
dc.contributor.author | Mok, Esther | |
dc.contributor.author | Kawanishi, Shohei | |
dc.contributor.author | Kitamura, Yoshihisa | |
dc.contributor.author | Larbi, Anis | |
dc.contributor.author | Poidinger, Michael | |
dc.contributor.author | Renia, Laurent | |
dc.contributor.author | Ng, Lai Guan | |
dc.contributor.author | Wolf, Yochai | |
dc.contributor.author | Jung, Steffen | |
dc.contributor.author | Onder, Tamer | |
dc.contributor.author | Newell, Evan | |
dc.contributor.author | Takata, Kazuyuki | |
dc.contributor.author | Kozaki, Tatsuya | |
dc.contributor.author | Lee, Christopher Zhe Wei | |
dc.contributor.author | Thion, Morgane Sonia | |
dc.contributor.author | Otsuka, Masayuki | |
dc.contributor.author | Lim, Shawn | |
dc.contributor.author | Utami, Kagistia Hana | |
dc.contributor.author | Fidan, Kerem | |
dc.contributor.author | Park, Dong Shin | |
dc.contributor.author | Malleret, Benoit | |
dc.contributor.author | Chakarov, Svetoslav | |
dc.contributor.author | Low, Donovan | |
dc.contributor.author | Low, Gillian | |
dc.contributor.author | Garcia-Miralles, Marta | |
dc.contributor.author | Zeng, Ruizhu | |
dc.date.accessioned | 2021-03-04T11:00:10Z | |
dc.date.available | 2021-03-04T11:00:10Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Takata K., Kozaki T., Lee C. Z. W. , Thion M. S. , Otsuka M., Lim S., Utami K. H. , Fidan K., Park D. S. , Malleret B., et al., "Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function", IMMUNITY, cilt.47, sa.1, ss.183-204, 2017 | |
dc.identifier.issn | 1074-7613 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_7014a175-6bb9-4962-a1f0-bbe7eb89b0dd | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/77285 | |
dc.identifier.uri | https://doi.org/10.1016/j.immuni.2017.06.017 | |
dc.description.abstract | Tissue macrophages arise during embryogenesis from yolk-sac (YS) progenitors that give rise to primitive YS macrophages. Until recently, it has been impossible to isolate or derive sufficient numbers of YS-derived macrophages for further study, but data now suggest that induced pluripotent stem cells (iPSCs) can be driven to undergo a process reminiscent of YS-hematopoiesis in vitro. We asked whether iPSC-derived primitive macrophages (iMacs) can terminally differentiate into specialized macrophages with the help of growth factors and organ-specific cues. Co-culturing human or murine iMacs with iPSC-derived neurons promoted differentiation into microglia-like cells in vitro. Furthermore, murine iMacs differentiated in vivo into microglia after injection into the brain and into functional alveolar macrophages after engraftment in the lung. Finally, iPSCs from a patient with familial Mediterranean fever differentiated into iMacs with pro-inflammatory characteristics, mimicking the disease phenotype. Altogether, iMacs constitute a source of tissue-resident macrophage precursors that can be used for biological, pathophysiological, and therapeutic studies. | |
dc.language.iso | eng | |
dc.subject | İmmünoloji | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Temel Bilimler | |
dc.title | Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function | |
dc.type | Makale | |
dc.relation.journal | IMMUNITY | |
dc.contributor.department | Agency for Science Technology & Research (ASTAR) , , | |
dc.identifier.volume | 47 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 183 | |
dc.identifier.endpage | 204 | |
dc.contributor.firstauthorID | 244359 | |