PDCD1 polymorphisms are not associated with Takayasu's arteritis in Turkey
Yazar
Bicakcigil, M
Akar, S
Önen, F
Seyahi, E
Onat, AM
Aydin, SZ
Yilmaz, N
Cefle, A
Cobankara, V
Tunc, E
Ozturk, MA
Fresko, I
Karaaslan, Y
Akkoc, N
Yücel, AE
Kiraz, S
Keser, G
Inanc, M
Saruhan-Direskeneli, Güher
Uyar, Fatma Aytül
Direskeneli, H
Tuna-Erdoğan, E
Gündüz, F
Bandurska-Luque, A
Alparslan, B
Kebe, M
Aksu, K
Kamali, S
Ozbalkan, Z
Ates, A
Karadag, O
Ozer, HT
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Objectives: Takayasu's arteritis (TA) is a chronic arterial inflammation of unknown etiology involving mainly the aorta and its major branches. Based on the associations of programmed death-1 (PD-1) protein encoding gene (PDCD1) with connective tissue diseases and vasculitides, PDCD1 polymorphisms are studied for susceptibility to TA in this study. Methods: The study group is made up of TA patients (n=229) fulfilling the 1990 ACR classification criteria and compared to 193 healthy controls (HC). PD-1.3, PD-1.5 and PD-1.6 single nucleotide polymorphisms of PDCD1 gene are genotyped by polymerase chain reaction and restriction analysis (PCR-RFLP). Results: The distribution of PD-1.5 polymorphism in TA patients and HC revealed a similar presence of TT genotype in patients and controls (13.3% vs. 11.4%). PD-1.3 and PD-1.6 were less polymorphic and did not differ between the groups. Rare AA genotype of PD-1.3 (1.4% vs. 1.0%) and AG genotype of PD-1.6 was again similarly (22.4% vs. 19.2%) present in TA and HC. Conclusion: PD-1.3, 1.5 and 1.6 polymorphisms of PDCD1 gene, which were shown to be associated with various autoimmune disorders and vasculitides, are not associated with a susceptibility to TA in Turkish population. © Clinical and Experimental Rheumatology 2012.
Bağlantı
http://hdl.handle.net/20.500.12627/78236https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84863735129&origin=inward
https://doi.org/10.1007/s00296-011-2127-0
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