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dc.contributor.authorOnal, Burak
dc.contributor.authorOzyazgan, Sibel
dc.contributor.authorAkkan, A. Gokhan
dc.contributor.authorKandaz, Cemre
dc.contributor.authorOzen, Deniz
dc.contributor.authorDemir, Bulent
dc.date.accessioned2021-03-04T11:29:45Z
dc.date.available2021-03-04T11:29:45Z
dc.date.issued2018
dc.identifier.citationKandaz C., Onal B., Ozen D., Demir B., Akkan A. G. , Ozyazgan S., "Investigation of MTHFR gene C677T polymorphism in cardiac syndrome X patients", JOURNAL OF CLINICAL LABORATORY ANALYSIS, cilt.32, sa.2, 2018
dc.identifier.issn0887-8013
dc.identifier.otherav_7295d26b-e84e-4079-85c3-e2a226bc0d43
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/78868
dc.identifier.urihttps://doi.org/10.1002/jcla.22247
dc.description.abstractBackgroundDefinition of Cardiac Syndrome X (CSX) refers to groups of patients with positive exercise stress test and normal epicardial coronary arteries on coronary angiography accompanied by chest pain. Although the etiology of CSX is not completely understood, there is a common consensus that its pathophysiology may be associated with endothelial dysfunction resulting in impaired coronary flow. Some polymorphisms observed on the MTHFR gene cause inactivation of the MTHFR enzyme, leading to hyperhomocysteinemia and homocysteinuria, which are prominent risk factors of cardiovascular and cerebrovascular diseases. It was aimed to explain the association of the endothelial dysfunction, which is thought to play a role in the pathophysiology of CSX, with C677T polymorphism on MTHFR gene based on genetic basis.
dc.language.isoeng
dc.subjectKlinik Tıp
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectTIBBİ LABORATUVAR TEKNOLOJİSİ
dc.titleInvestigation of MTHFR gene C677T polymorphism in cardiac syndrome X patients
dc.typeMakale
dc.relation.journalJOURNAL OF CLINICAL LABORATORY ANALYSIS
dc.contributor.departmentSağlık Bilimleri Üniversitesi , ,
dc.identifier.volume32
dc.identifier.issue2
dc.contributor.firstauthorID33215


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