dc.contributor.author | Gorgun, Didem | |
dc.contributor.author | Midilli, Kenan | |
dc.contributor.author | Secik, Funda | |
dc.contributor.author | Akkaya, Vakur | |
dc.contributor.author | Yildiz, Pinar | |
dc.date.accessioned | 2021-03-04T11:47:01Z | |
dc.date.available | 2021-03-04T11:47:01Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Gorgun D., Secik F., Midilli K., Akkaya V., Yildiz P., "Diagnostic and prognostic significance of survivin levels in malignant pleural effusion", RESPIRATORY MEDICINE, cilt.107, sa.8, ss.1260-1265, 2013 | |
dc.identifier.issn | 0954-6111 | |
dc.identifier.other | av_741ca8d0-ef9a-43c4-9a10-6facd4914c2d | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/79808 | |
dc.identifier.uri | https://doi.org/10.1016/j.rmed.2013.04.011 | |
dc.description.abstract | We aimed to evaluate the diagnostic and prognostic value of measuring survivin levels, which is an inhibitor of apoptosis in pleural effusions. Methods: Group I, malignant (MPE) (n = 51); Group II, tuberculosis (TPE) (n = 18); Group III transudative (TE) (n = 9) effusions were enrolled prospectively. We used ELISA to analyze 78 effusions. The value for the differential diagnosis and the correlation between survivin and survival in MPE were analyzed. Results: Survivin level was 41.75 +/- 76.20 in MPE, 15.83 +/- 10.92 in TPE and 8.33 +/- 8.67 in TE. When the patients divided two groups as malignant and non-malignant pleural effusion (non-MPE), survivin level was significantly higher in MPE (41.75 +/- 76.20) than in non-MPE (13.33 +/- 2.05) (p = 0.012). The cutoff value for survivin levels detected by ROC curve analysis was 7.5 pg/ml, with sensitivity and specificity values of 72%, 44%, respectively. Survivin had no discriminative power in differentiating exudative effusions of MPE from TPE (p = 0.405). There was no correlation between survivin level and age, sex, location, fluid pH, glucose, protein, albumine and ADA level while there was significant moderate correlation with fluid LDH (r = 0.49; p < 0.001). Survivin levels can distinguish patients who had poor prognosis (median survival 75 days, n = 24) and those who had good prognosis (median survival 219 days, n = 27, p = 0.03) in MPE. | |
dc.language.iso | eng | |
dc.subject | Kardiyoloji | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Göğüs Hastalıkları ve Allerji | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | SOLUNUM SİSTEMİ | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | CARDIAC ve CARDIOVASCULAR SİSTEMLER | |
dc.title | Diagnostic and prognostic significance of survivin levels in malignant pleural effusion | |
dc.type | Makale | |
dc.relation.journal | RESPIRATORY MEDICINE | |
dc.contributor.department | Istanbul Yedikule Chest Diseases & Thoracic Surgery Training & Research Hospital , , | |
dc.identifier.volume | 107 | |
dc.identifier.issue | 8 | |
dc.identifier.startpage | 1260 | |
dc.identifier.endpage | 1265 | |
dc.contributor.firstauthorID | 43373 | |