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dc.contributor.authorTunesi, Mawada
dc.contributor.authorKilislioglu, Ayben
dc.contributor.authorKalwar, Nazar Hussain
dc.contributor.authorWillander, Magnus
dc.contributor.authorKarakus, Selcan
dc.contributor.authorAbbas, Zaheer
dc.contributor.authorSoomro, Razium Ali
dc.date.accessioned2021-03-04T11:53:21Z
dc.date.available2021-03-04T11:53:21Z
dc.date.issued2020
dc.identifier.citationAbbas Z., Soomro R. A. , Kalwar N. H. , Tunesi M., Willander M., Karakus S., Kilislioglu A., "In Situ Growth of CuWO4 Nanospheres over Graphene Oxide for Photoelectrochemical (PEC) Immunosensing of Clinical Biomarker", SENSORS, cilt.20, sa.1, 2020
dc.identifier.issn1424-8220
dc.identifier.otherav_7491b474-d835-4966-b939-c8a1e8009a3c
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/80122
dc.identifier.urihttps://doi.org/10.3390/s20010148
dc.description.abstractProcalcitonin (PCT) protein has recently been identified as a clinical marker for bacterial infections based on its better sepsis sensitivity. Thus, an increased level of PCT could be linked with disease diagnosis and therapeutics. In this study, we describe the construction of the photoelectrochemical (PEC) PCT immunosensing platform based on it situ grown photo-active CuWO4 nanospheres over reduced graphene oxide layers (CuWO4@rGO). The in situ growth strategy enabled the formation of small nanospheres (diameter of 200 nm), primarily composed of tiny self-assembled CuWO4 nanoparticles (2-5 nm). The synergic coupling of CuWO4 with rGO layers constructed an excellent photo-active heterojunction for photoelectrochemical (PEC) sensing. The platform was then considered for electrocatalytic (EC) mechanism-based detection of PCT, where inhibition of the photocatalytic oxidation signal of ascorbic acid (AA), subsequent to the antibody-antigen interaction, was recorded as the primary signal response. This inhibition detection approach enabled sensitive detection of PCT in a concentration range of 10 pgmL(-1) to 50 ng.mL(-1) with signal sensitivity achievable up to 0.15 pgmL(-1). The proposed PEC hybrid (CuWO4@rGO) could further be engineered to detect other clinically important species.
dc.language.isoeng
dc.subjectSinyal İşleme
dc.subjectAnalitik Kimya
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectALETLER & GÖSTERİM
dc.subjectBilgi Sistemleri, Haberleşme ve Kontrol Mühendisliği
dc.subjectMühendislik, Bilişim ve Teknoloji (ENG)
dc.subjectMühendislik
dc.subjectMÜHENDİSLİK, ELEKTRİK VE ELEKTRONİK
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectKİMYA, ANALİTİK
dc.titleIn Situ Growth of CuWO4 Nanospheres over Graphene Oxide for Photoelectrochemical (PEC) Immunosensing of Clinical Biomarker
dc.typeMakale
dc.relation.journalSENSORS
dc.contributor.departmentBeijing University of Chemical Technology , ,
dc.identifier.volume20
dc.identifier.issue1
dc.contributor.firstauthorID2276703


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