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Myasthenia gravis patients with low plasma IL-6 and IFN-gamma benefit from etanercept treatment

dc.contributor.authorROWIN, J
dc.contributor.authorTuzun, Erdem
dc.contributor.authorYANG, H
dc.contributor.authorCHRISTADOSS, P
dc.contributor.authorMERIGGIOLI, MN
dc.date.accessioned2021-03-04T12:20:13Z
dc.date.available2021-03-04T12:20:13Z
dc.date.issued2005
dc.identifier.citationTuzun E., MERIGGIOLI M., ROWIN J., YANG H., CHRISTADOSS P., "Myasthenia gravis patients with low plasma IL-6 and IFN-gamma benefit from etanercept treatment", JOURNAL OF AUTOIMMUNITY, cilt.24, sa.3, ss.261-268, 2005
dc.identifier.issn0896-8411
dc.identifier.otherav_76c3149d-a9a7-4934-a53c-9628c203b835
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/81548
dc.identifier.urihttps://doi.org/10.1016/j.jaut.2005.01.013
dc.description.abstractSteroid-dependent myasthenia gravis patients improved following treatment with etanercept (recombinant human TNF receptor: Fc) in a prospective pilot trial. While the plasma anti -acetylcholine receptor antibody levels remained unaffected, etanercept treatment increased plasma levels of C3, circulating immune coniplexes, IL-10 and IFN-gamma. There was a direct correlation between plasma IL-6, TNF-alpha and IFN-gamma levels and the post-treatment clinical scores of patients. Moreover, patients with lower pretreatment plasma IL-6 and IFN-gamma levels attained better clinical improvement following etanercept treatment. (c) 2005 Elsevier Ltd. All rights reserved.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectİmmünoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTemel Bilimler
dc.titleMyasthenia gravis patients with low plasma IL-6 and IFN-gamma benefit from etanercept treatment
dc.typeMakale
dc.relation.journalJOURNAL OF AUTOIMMUNITY
dc.contributor.department, ,
dc.identifier.volume24
dc.identifier.issue3
dc.identifier.startpage261
dc.identifier.endpage268
dc.contributor.firstauthorID1842


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