Thrombolytic Therapy for the Treatment of Prosthetic Heart Valve Thrombosis in Pregnancy With Low-Dose, Slow Infusion of Tissue-Type Plasminogen Activator

Date
2013
Author
Gursoy, Ozan Mustafa
Gunduz, Sabahattin
ASTARCIOĞLU, MEHMET ALİ
Aykan, Ahmet Cagri
Bayram, Zubeyde
Biteker, Murat
Kaynak, Evren
Kahveci, Gokhan
Duran, Nilufer Eksi
Yildiz, Mustafa
Ozkan, Mehmet
Cakal, Beytullah
Karakoyun, Suleyman
Cevik, Cihan
Kalcik, Macit
Oguz, Ali Emrah
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Abstract
Background-Prosthetic valve thrombosis during pregnancy is life-threatening for mother and fetus, and the treatment of this complication is unclear. Cardiac surgery in pregnancy is associated with very high maternal and fetal mortality and morbidity. Thrombolytic therapy has rarely been used in these patients. The aim of this study is to evaluate the safety and efficacy of low-dose (25 mg), slow infusion (6 hours) of tissue-type plasminogen activator for the treatment of prosthetic valve thrombosis in pregnant women.
URI
http://hdl.handle.net/20.500.12627/81753
https://doi.org/10.1161/circulationaha.113.001145
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