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dc.contributor.authorGurkaynak, Tuba Altincekic
dc.contributor.authorOzhan, Gül
dc.contributor.authorAbudayyak, Mahmoud
dc.date.accessioned2021-03-04T12:43:40Z
dc.date.available2021-03-04T12:43:40Z
dc.date.issued2017
dc.identifier.citationAbudayyak M., Gurkaynak T. A. , Ozhan G., "Assessment of Cellular Responses in Kidney Cells Exposed to Cobalt Oxide Nanoparticles", MARMARA PHARMACEUTICAL JOURNAL, cilt.21, sa.3, ss.537-543, 2017
dc.identifier.othervv_1032021
dc.identifier.otherav_78c08508-3f7d-40ce-87e8-5e7d502ef379
dc.identifier.urihttp://hdl.handle.net/20.500.12627/82805
dc.identifier.urihttps://doi.org/10.12991/marupj.318619
dc.description.abstractCobalt oxide (Co3O4) nanoparticles have been extensively used in various industrial and medical applications due to their special optical, magnetic, and electrical activity features. However, there is a lack of information about their toxicity and adverse effects on human health, especially concerning the kidney, which is considered to be a secondary target organ. We investigated the toxic potentials of Co3O4 nanoparticles on NRK-52E kidney epithelial cells by in vitro assays. CO3O4 nanoparticles were taken up by the kidney cells, and caused a decrease in cell viability, by significantly inducing apoptosis/necrosis at 100 mu g/mL. However, no significant DNA damage was observed. Co(3)O(4)nanoparticles induced cellular toxicity in kidney cells. These results should raise concern about the safety of Co3O4 nanoparticles in their various applications. Further studies are needed to elucidate their toxic mechanism.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectEczacılık
dc.subjectYaşam Bilimleri
dc.subjectTemel Eczacılık Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.titleAssessment of Cellular Responses in Kidney Cells Exposed to Cobalt Oxide Nanoparticles
dc.typeMakale
dc.relation.journalMARMARA PHARMACEUTICAL JOURNAL
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume21
dc.identifier.issue3
dc.identifier.startpage537
dc.identifier.endpage543
dc.contributor.firstauthorID65571


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