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dc.contributor.authorSchrier, Robert W.
dc.contributor.authorEcder, Tevfik
dc.date.accessioned2021-03-04T12:46:22Z
dc.date.available2021-03-04T12:46:22Z
dc.date.issued2009
dc.identifier.citationEcder T., Schrier R. W. , "Cardiovascular abnormalities in autosomal-dominant polycystic kidney disease", NATURE REVIEWS NEPHROLOGY, cilt.5, sa.4, ss.221-228, 2009
dc.identifier.issn1759-5061
dc.identifier.otherav_7901f9ac-335e-437f-9eb0-f145790f9de6
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/82973
dc.identifier.urihttps://doi.org/10.1038/nrneph.2009.13
dc.description.abstractCardiovascular problems are a major cause of morbidity and mortality in patients with autosomal-dominant polycystic kidney disease (ADPKD). Hypertension is a common early symptom of ADPKD, and occurs in approximately 60% of patients before renal function has become impaired. Hypertension is associated with an increased rate of progression to end-stage renal disease and is the most important potentially treatable variable in ADPKD. Left ventricular hypertrophy, which is a powerful, independent risk factor for cardiovascular morbidity and mortality, also occurs frequently in patients with ADPKD. Both hypertension and left ventricular hypertrophy have important roles in cardiovascular complications in these individuals. Moreover, biventricular diastolic dysfunction, endothelial dysfunction, increased carotid intima-media thickness, and impaired coronary flow velocity reserve are present even in young patients with ADPKD who have normal blood pressure and well-preserved renal function. These findings suggest that cardiovascular involvement starts very early in the course of ADPKD. intracranial and extracranial aneurysms and cardiac valvular defects are other potential cardiovascular problems in patients with ADPKD. early diagnosis and treatment of hypertension, with drugs that block the renin-angiotensin-aldosterone system, has the potential to decrease the cardiovascular complications and slow the progression of renal disease in ADPKD.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectNefroloji
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectÜROLOJİ VE NEFROLOJİ
dc.titleCardiovascular abnormalities in autosomal-dominant polycystic kidney disease
dc.typeMakale
dc.relation.journalNATURE REVIEWS NEPHROLOGY
dc.contributor.departmentUniversity of Colorado System , ,
dc.identifier.volume5
dc.identifier.issue4
dc.identifier.startpage221
dc.identifier.endpage228
dc.contributor.firstauthorID192110


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