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dc.contributor.authorGUNER, Rahmet
dc.contributor.authorKoruk, Suda Tekin
dc.contributor.authorKoruk, Ibrahim
dc.contributor.authorErbay, Ayse
dc.contributor.authorTEZER-TEKCE, Yasemin
dc.contributor.authorErbay, Ali Riza
dc.contributor.authorDayan, Saim
dc.contributor.authorDeveci, Ozcan
dc.contributor.authorINAN, Asuman
dc.contributor.authorENGIN, Derya Ozturk
dc.contributor.authorDikici, Nebahat
dc.contributor.authorDoyuk-Kartal, Elif
dc.contributor.authorKurtaran, Behice
dc.contributor.authorPehlivanoğlu, Filiz
dc.contributor.authorSipahi, Oguz Resat
dc.contributor.authorYalci, Aysun
dc.contributor.authorAlp-Cavus, Sema
dc.contributor.authorGENCER, Serap
dc.contributor.authorGuzel, Gokhan
dc.contributor.authorParlak, Mehmet
dc.contributor.authorKazak, Esra
dc.contributor.authorTULEK, Necla
dc.contributor.authorULCAY, Asim
dc.contributor.authorSAVASCI, Umit
dc.contributor.authorONCUL, Oral
dc.contributor.authorYemisen, Mücahit
dc.contributor.authorERDEM, Hakan
dc.date.accessioned2021-03-04T12:48:58Z
dc.date.available2021-03-04T12:48:58Z
dc.date.issued2012
dc.identifier.citationKoruk S. T. , ERDEM H., Koruk I., Erbay A., TEZER-TEKCE Y., Erbay A. R. , Dayan S., Deveci O., INAN A., ENGIN D. O. , et al., "Management of Brucella endocarditis: results of the Gulhane study", INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, cilt.40, sa.2, ss.145-150, 2012
dc.identifier.issn0924-8579
dc.identifier.otherav_7935a2fe-bd0d-461e-bf54-853063099bcb
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/83097
dc.identifier.urihttps://doi.org/10.1016/j.ijantimicag.2012.04.009
dc.description.abstractBrucella endocarditis (BE) is a rare but life-threatening complication of human brucellosis. The aim of this study was to investigate the course of BE along with the therapeutic interrelations. A total of 53 patients with BE hospitalised in 19 health institutions between 2006 and 2011 were included in the Gulhane study. Diagnosis of brucellosis was established by either isolation of Brucella sp. or the presence of antibodies, and the definition of endocarditis was made according to Duke's criteria. There were four treatment groups: ceftriaxone combined with oral antibiotics (Group 1); aminoglycosides combined with oral antibiotics (Group 2); oral antibiotic combinations (Group 3); and aminoglycoside plus ceftriaxone combined with an oral antibiotic (Group 4). Involvement rates of the aortic, mitral and tricuspid valves were 49.1%, 43.4% and 5.7%, respectively. Thirty-two patients (60.4%) had an underlying cardiac valvular problem, including previous prosthetic valve replacement (n = 18). Medical treatment was provided to 32 patients (60.4%), whilst concordant medical and surgical approaches were provided to 21 patients (39.6%). Mortality in Group 1 was 15% (3/20), whilst in Group 2 it was 5.3% (1/19). In Group 3, 25.0% (3/12) of the cases died, whereas none of the cases in Group 4 died. In conclusion, mortality increased 47-fold with pericardial effusion and 25-fold due to congestive heart failure that developed after BE. Although mortality was lower in the aminoglycoside-containing arm (Groups 2 and 4), statistical analysis could not be performed owing to the small number of patients. (C) 2012 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
dc.language.isoeng
dc.subjectEczacılık
dc.subjectBULAŞICI HASTALIKLAR
dc.subjectİmmünoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMikrobiyoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectSağlık Bilimleri
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.titleManagement of Brucella endocarditis: results of the Gulhane study
dc.typeMakale
dc.relation.journalINTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
dc.contributor.departmentHarran Üniversitesi , ,
dc.identifier.volume40
dc.identifier.issue2
dc.identifier.startpage145
dc.identifier.endpage150
dc.contributor.firstauthorID73424


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