Serum Nitrosative Stress Levels Are Increased in Alzheimer Disease but Not in Vascular Dementia
Tarih
2010Yazar
Sinem, Firtina
Gokhan, Erkol
Dildar, Konukoglu
Orhan, Yagiz
Filiz, Manga
Üst veri
Tüm öğe kaydını gösterÖzet
The aim of this study was to investigate whether there is a difference between Alzheimer disease (AD) dementia and pure vascular dementia (VaD) in relation to nitrosative stress levels. We determined serum nitric oxide (NO), oxidized low-density lipoproteins (ox-LDL), and 3-nitrotyrosine levels (3-NT) in healthy elderly individuals (controls, n = 15, mean age = 73.4 +/- 7.9 y), AD patients (n = 30; mean age = 71.2 +/- 12.7 y) and VaD patients (n = 20; mean age = 75.2 +/- 7.5 y). Patients were under anticholinesterase drug therapy. Our results showed that serum NO and ox-LDL levels in AD patients group were significantly higher than in both controls (P < 0.001 and P < 0.001) and VaD patients (P < 0.01 and P < 0.001). However, no significant differences in plasma NO and ox-LDL levels were found between VaD and controls. Our study did not reveal significant differences in plasma 3-NT values of dementia patients when compared with controls. There was a significant negative correlation between Mini-Mental State Examination score and serum NO levels in dementia patients (r = -0.349, P < 0.01). Serum NO levels were also positively correlated with serum ox-LDL levels (r = 0.358, P < 0.01). In conclusion, elevation in serum levels of NO was present in probable AD patients but not in VaD patients, and this seems to be related to both ox-LDL levels and cognitive status.
Koleksiyonlar
- Makale [92796]