dc.contributor.author | Sinem, Firtina | |
dc.contributor.author | Gokhan, Erkol | |
dc.contributor.author | Dildar, Konukoglu | |
dc.contributor.author | Orhan, Yagiz | |
dc.contributor.author | Filiz, Manga | |
dc.date.accessioned | 2021-03-04T13:05:57Z | |
dc.date.available | 2021-03-04T13:05:57Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Dildar K., Sinem F., Gokhan E., Orhan Y., Filiz M., "Serum Nitrosative Stress Levels Are Increased in Alzheimer Disease but Not in Vascular Dementia", ALZHEIMER DISEASE & ASSOCIATED DISORDERS, cilt.24, sa.2, ss.194-197, 2010 | |
dc.identifier.issn | 0893-0341 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_7a989549-a3e2-44e9-8e8f-158ea2d3c923 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/83980 | |
dc.identifier.uri | https://doi.org/10.1097/wad.0b013e3181c53d0d | |
dc.description.abstract | The aim of this study was to investigate whether there is a difference between Alzheimer disease (AD) dementia and pure vascular dementia (VaD) in relation to nitrosative stress levels. We determined serum nitric oxide (NO), oxidized low-density lipoproteins (ox-LDL), and 3-nitrotyrosine levels (3-NT) in healthy elderly individuals (controls, n = 15, mean age = 73.4 +/- 7.9 y), AD patients (n = 30; mean age = 71.2 +/- 12.7 y) and VaD patients (n = 20; mean age = 75.2 +/- 7.5 y). Patients were under anticholinesterase drug therapy. Our results showed that serum NO and ox-LDL levels in AD patients group were significantly higher than in both controls (P < 0.001 and P < 0.001) and VaD patients (P < 0.01 and P < 0.001). However, no significant differences in plasma NO and ox-LDL levels were found between VaD and controls. Our study did not reveal significant differences in plasma 3-NT values of dementia patients when compared with controls. There was a significant negative correlation between Mini-Mental State Examination score and serum NO levels in dementia patients (r = -0.349, P < 0.01). Serum NO levels were also positively correlated with serum ox-LDL levels (r = 0.358, P < 0.01). In conclusion, elevation in serum levels of NO was present in probable AD patients but not in VaD patients, and this seems to be related to both ox-LDL levels and cognitive status. | |
dc.language.iso | eng | |
dc.subject | Patoloji | |
dc.subject | Cerrahi Tıp Bilimleri | |
dc.subject | Nöroloji | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Biyokimya | |
dc.subject | KLİNİK NEUROLOJİ | |
dc.subject | Klinik Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | PATOLOJİ | |
dc.subject | Biyoloji ve Biyokimya | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Temel Tıp Bilimleri | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Temel Bilimler | |
dc.subject | Yaşam Bilimleri | |
dc.title | Serum Nitrosative Stress Levels Are Increased in Alzheimer Disease but Not in Vascular Dementia | |
dc.type | Makale | |
dc.relation.journal | ALZHEIMER DISEASE & ASSOCIATED DISORDERS | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 24 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 194 | |
dc.identifier.endpage | 197 | |
dc.contributor.firstauthorID | 195673 | |