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Snythesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H-4 receptor antagonists

dc.contributor.authorvan Rijn, RM
dc.contributor.authorLeurs, R
dc.contributor.authorBakker, RA
dc.contributor.authorDe Esch, IJP
dc.contributor.authorTerzioglu, N
dc.date.accessioned2021-03-04T13:29:30Z
dc.date.available2021-03-04T13:29:30Z
dc.date.issued2004
dc.identifier.citationTerzioglu N., van Rijn R., Bakker R., De Esch I., Leurs R., "Snythesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H-4 receptor antagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, cilt.14, sa.21, ss.5251-5256, 2004
dc.identifier.issn0960-894X
dc.identifier.otherav_7ca8836e-7e3c-47b1-b84a-6fef13d556c4
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/85245
dc.identifier.urihttps://doi.org/10.1016/j.bmcl.2004.08.035
dc.description.abstractWe describe the structure-activity relationships for a series of ligands structurally related to the recently identified (5-chloro-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone (1) as histamine H-4 receptor (H4R) antagonists. Furthermore we identified related benzimidazoles as novel lead compounds for the H4R. The ligands have been evaluated by radioligand displacement studies and functional assays for their interaction with both the human histamine H-3 and H-4 receptors and exhibit pK(i) values up to 7.5 at the human H4R. (C) 2004 Elsevier Ltd. All rights reserved.
dc.language.isoeng
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectBiyokimya
dc.subjectBiyoinorganik Kimya
dc.subjectTemel Bilimler
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSağlık Bilimleri
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectKİMYA, ORGANİK
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectKİMYA, TIP
dc.titleSnythesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H-4 receptor antagonists
dc.typeMakale
dc.relation.journalBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
dc.contributor.department, ,
dc.identifier.volume14
dc.identifier.issue21
dc.identifier.startpage5251
dc.identifier.endpage5256
dc.contributor.firstauthorID173103


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