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dc.contributor.authorUitto, Veli-Jukka
dc.contributor.authorGursoy, Ulvi K.
dc.contributor.authorFonseca Moreira, Jose Claudio
dc.contributor.authorKeskin, Mutlu
dc.contributor.authorKononen, Eija
dc.contributor.authorSoderling, Eva
dc.contributor.authorZeidan-Chulia, Fares
dc.date.accessioned2021-03-04T14:19:35Z
dc.date.available2021-03-04T14:19:35Z
dc.date.issued2015
dc.identifier.citationZeidan-Chulia F., Keskin M., Kononen E., Uitto V., Soderling E., Fonseca Moreira J. C. , Gursoy U. K. , "Antibacterial and Antigelatinolytic Effects of Satureja hortensis L. Essential Oil on Epithelial Cells Exposed to Fusobacterium nucleatum", JOURNAL OF MEDICINAL FOOD, cilt.18, sa.4, ss.503-506, 2015
dc.identifier.issn1096-620X
dc.identifier.othervv_1032021
dc.identifier.otherav_80ed3b1f-3816-40e2-8b29-e55d8a9f95ca
dc.identifier.urihttp://hdl.handle.net/20.500.12627/87908
dc.identifier.urihttps://doi.org/10.1089/jmf.2013.0052
dc.description.abstractThe present report examined the effects of essential oils (EOs) from Satureja hortensis L. and Salvia fruticosa M. on the viability and outer membrane permeability of the periodontopathogen Fusobacterium nucleatum, a key bacteria in oral biofilms, as well as the inhibition of matrix metalloproteinase (MMP-2 and MMP-9) activities in epithelial cells exposed to such bacteria. Membrane permeability was tested by measuring the N-phenyl-1-naphthylamine uptake and bacterial viability by using the commercially available Live/Dead BacLight kit. In addition, gelatin zymography was performed to analyze the inhibition of F. nucleatum-induced MMP-2 and MMP-9 activities in HaCaT cells. We showed that 5, 10, and 25 mu L/mL of Sat. hortensis L. EO decreased the ratio of live/dead bacteria and increased the outer membrane permeability in a range of time from 0 to 5 min. Treatments with 10 and 25 mu L/mL of Sal. fruticosa M. also increased the membrane permeability and 5, 10, and 25 mu L/mL of both EOs inhibited MMP-2 and MMP-9 activities in keratinocytes induced after exposure of 24 h to F. nucleatum. We conclude that antibacterial and antigelatinolytic activities of Sat. hortensis L. EO have potential for the treatment of periodontal inflammation.
dc.language.isoeng
dc.subjectMühendislik ve Teknoloji
dc.subjectTemel Bilimler
dc.subjectKİMYA, TIP
dc.subjectKimya
dc.subjectTemel Bilimler (SCI)
dc.subjectGIDA BİLİMİ VE TEKNOLOJİSİ
dc.subjectTarım Bilimleri
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectBESLENME VE DİYETETİK
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectBeslenme ve Dietetik
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectGıda Mühendisliği
dc.subjectYaşam Bilimleri
dc.subjectBiyokimya
dc.titleAntibacterial and Antigelatinolytic Effects of Satureja hortensis L. Essential Oil on Epithelial Cells Exposed to Fusobacterium nucleatum
dc.typeMakale
dc.relation.journalJOURNAL OF MEDICINAL FOOD
dc.contributor.departmentFed Univ Rio Grande do Sul UFRGS , ,
dc.identifier.volume18
dc.identifier.issue4
dc.identifier.startpage503
dc.identifier.endpage506
dc.contributor.firstauthorID221666


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