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dc.contributor.authorArtun, B. C.
dc.contributor.authorGulluoglu, Mine
dc.contributor.authorUysal, M.
dc.contributor.authorKusku-Kiraz, Z.
dc.contributor.authorKocak-Toker, N.
dc.contributor.authorCevikbas, U.
dc.date.accessioned2021-03-04T14:59:54Z
dc.date.available2021-03-04T14:59:54Z
dc.date.issued2010
dc.identifier.citationArtun B. C. , Kusku-Kiraz Z., Gulluoglu M., Cevikbas U., Kocak-Toker N., Uysal M., "The effect of carnosine pretreatment on oxidative stress and hepatotoxicity in binge ethanol administered rats", HUMAN & EXPERIMENTAL TOXICOLOGY, cilt.29, sa.8, ss.659-665, 2010
dc.identifier.issn0960-3271
dc.identifier.othervv_1032021
dc.identifier.otherav_84733d87-fa3c-4acd-8502-5c95eaa03751
dc.identifier.urihttp://hdl.handle.net/20.500.12627/90093
dc.identifier.urihttps://doi.org/10.1177/0960327109359460
dc.description.abstractCarnosine is a dipeptide having strong antioxidant effects. Oxidative stress plays an important role in pathogenesis of alcohol-induced liver injury. In this study, we investigated the effect of carnosine pretreatment on ethanol-induced oxidative stress and hepatotoxicity. Rats were given carnosine (2 g/L in drinking water) for 4 weeks and then ethanol was administered orally to rats at a dose of 5 g/kg every 12 hours for 3 doses totally (binge model). All rats were killed 6 hours after last ethanol injection. Plasma alanine (ALT) and aspartate (AST) transaminase activities and liver triglyceride, malondialdehyde (MDA), diene conjugate (DC), glutathione (GSH), vitamin E and vitamin C levels and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and glutathione transferase (GST) activities were determined. Binge ethanol administration resulted in significant increases in plasma transaminase activities, hepatic triglyceride and lipid peroxide levels. However, GSH, vitamin E, vitamin C levels and GSH-Px and GST activities were found to be decreased following ethanol administration. Macromicrovesicular steatosis was also seen. Carnosine pretreatment appeared to prevent the increase of plasma ALT and AST activities and hepatic MDA and DC levels following ethanol treatment. In addition, hepatic GSH levels increased, but there were no changes in triglyceride, vitamin E, vitamin C levels and SOD, GSH-Px and GST activities, following ethanol treatment in carnosine-pretreated rats. There was also no change in liver histopathological appearance. In conclusion, carnosine prevented the increases in serum transaminase activities and lipid peroxides in liver of ethanol-treated rats, without any change on steatosis in liver.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectFarmasötik Toksikoloji
dc.subjectYaşam Bilimleri
dc.subjectMeslek Bilimleri
dc.subjectEczacılık
dc.subjectSağlık Bilimleri
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectTOKSİKOLOJİ
dc.titleThe effect of carnosine pretreatment on oxidative stress and hepatotoxicity in binge ethanol administered rats
dc.typeMakale
dc.relation.journalHUMAN & EXPERIMENTAL TOXICOLOGY
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume29
dc.identifier.issue8
dc.identifier.startpage659
dc.identifier.endpage665
dc.contributor.firstauthorID17028


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