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dc.contributor.authorGeltınk, Ramon Klein
dc.contributor.authorNumata, Masashi
dc.contributor.authorYener, Mehmet Deniz
dc.contributor.authorGrosveld, Gerard
dc.contributor.authorCardone, Monica
dc.contributor.authorTerranova, Sabrina
dc.contributor.authorOzcelik, Emrah
dc.contributor.authorAnak, Sema
dc.contributor.authorKaraman, Serap
dc.contributor.authorOzturk, Gulyuz
dc.contributor.authorKandilci, Ayten
dc.contributor.authorOzbek, Uğur
dc.contributor.authorAydin, Müge
dc.contributor.authorEkmekci, Sema
dc.contributor.authorGulec, Çağrı
dc.contributor.authorAkbıyık, Meral
dc.date.accessioned2021-03-04T15:01:12Z
dc.date.available2021-03-04T15:01:12Z
dc.identifier.citationNumata M., Yener M. D. , Ekmekci S., Aydin M., Grosveld G., Cardone M., Terranova S., Geltınk R. K. , Ozbek U., Ozcelik E., et al., "High MN1 expression increases the in vitro clonogenic activity of primary mouse B-cells.", Leukemia research, cilt.39, ss.906-12, 2015
dc.identifier.issn0145-2126
dc.identifier.othervv_1032021
dc.identifier.otherav_84972da5-9157-4c1f-b4c1-49a4dad5c1a9
dc.identifier.urihttp://hdl.handle.net/20.500.12627/90179
dc.identifier.urihttps://doi.org/10.1016/j.leukres.2015.05.013
dc.description.abstractThe MN1 (Meningioma 1) gene is overexpressed in certain subtypes of acute myeloid leukemia (AML) and high levels of MN1 expression in mouse bone marrow cells results in myeloid leukemia. We showed that compared with control bone marrow (BM) MN1 expression was increased (2-fold or more) in 29 out of 73 (40%) pediatric B-cell acute lymphoblastic leukemia (B-ALL) patient BM. Additional analysis of MN1 expression in sub-groups within our cohort carrying different chromosome translocations showed that carriers of the good prognostic marker t(12;21)(TEL-AML1) (n = 27) expressed significantly more MN1 than both healthy controls (n = 9) (P = 0.02) and the group carrying the t(9; 22)(BCR-ABL) (n = 9) (P = 0.001). In addition, AML1 expression was also upregulated in 31 out of 45 (68%) B-ALL patient BM compared with control and there was a significant correlation between MN1 and AML1 expression (r = 0.3552, P = 0.0167). Retroviral MN1 overexpression increased the colony forming activity of mouse Pro-B/Pre-B cells in vitro. Our results suggest that deregulated MN1 expression contributes to the pathogenesis of pediatric BALL. Further investigation into the clinical and biological significance of elevated MN1 expression in TEL-AML1(positive) leukemia might provide insight into additional molecular mechanisms contributing to B-ALL and may lead to improved treatment options for patients. (C) 2015 Elsevier Ltd. All rights reserved.
dc.language.isoeng
dc.subjectHEMATOLOJİ
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectONKOLOJİ
dc.subjectKlinik Tıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectOnkoloji
dc.subjectHematoloji
dc.subjectKlinik Tıp (MED)
dc.titleHigh MN1 expression increases the in vitro clonogenic activity of primary mouse B-cells.
dc.typeMakale
dc.relation.journalLeukemia research
dc.contributor.departmentSt Jude Children''s Research Hospital , ,
dc.identifier.volume39
dc.identifier.startpage906
dc.identifier.endpage12
dc.contributor.firstauthorID1040849


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