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dc.contributor.authorGulbaba, RG
dc.contributor.authorAkhan, S
dc.contributor.authorTurfanda, A
dc.contributor.authorBuyukoren, A
dc.contributor.authorEserol, F
dc.contributor.authorBaysal, B
dc.date.accessioned2021-03-02T20:57:54Z
dc.date.available2021-03-02T20:57:54Z
dc.date.issued1997
dc.identifier.citationBaysal B., Turfanda A., Gulbaba R., Buyukoren A., Eserol F., Akhan S., "Endometrial levels of insulin-like growth factor-1 receptors and insulin-like growth factor binding protein-1 in perimenopausal simple endometrial hyperplasia", MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, cilt.4, sa.1, ss.24-27, 1997
dc.identifier.issn1072-3714
dc.identifier.othervv_1032021
dc.identifier.otherav_04aaaa1c-2102-405c-bda4-d6f8f8a8833d
dc.identifier.urihttp://hdl.handle.net/20.500.12627/9051
dc.description.abstractThe objective of this study was to evaluate the endometrial levels of insulinlike growth factor-1 (IGF-1) receptors and insulin-like growth factor binding protein-1 (IGFBP-1) in perimenopausal simple endometrial hyperplasia and in proliferative endometrium. Because unopposed estrogen stimulation is a risk factor for hyperplasia and cancer of the endometrium, it is possible that estrogen-mediated effects on IGF-1 receptors and IGFBP-1 may play an important role in the development of endometrial hyperplasia. Tissue samples were taken from 179 women >35 years of age seeking treatment for menometrorrhagia. Twenty-six of the endometrial samples revealed simple hyperplasia and 18 specimens that showed proliferative endometrium were included as a control group. All patients in both of the groups had normal body mass indexes and fasting serum insulin levels. Endometrial levels of IGF-1 receptors were measured by the labelled ligand receptor complex technique, and levels of IGFBP-1 were assessed by delayed tracer addition radioimmunoassay. Endometrial IGF-1 receptor levels in proliferative endometrium and simple hyperplasia were 16.94 +/- 5.02 and 17.18 +/- 4.12 nmol/mg, respectively, whereas IGFBP-1 levels were 1,760.19 +/- 461.33 and 2,092.77 +/- 334.47 mU/ml, respectively. Although IGF-1 receptor levels in proliferative endometrium showed no statistical difference from hyperplastic endometrium, IGFBP-1 levels in the hyperplasia group were significantly higher when compared with those levels in proliferative endometrium (p < 0.05). Our data illustrate possible estrogen effects on endometrial IGFBP-1 levels and suggest that IGFBP-1 may play an important role in regulating endometrial growth in both normal and hyperplastic endometrium.
dc.language.isoeng
dc.subjectCerrahi Tıp Bilimleri
dc.subjectKadın Hastalıkları ve Doğum
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectKADIN HASTALIKLARI & DOĞUM
dc.titleEndometrial levels of insulin-like growth factor-1 receptors and insulin-like growth factor binding protein-1 in perimenopausal simple endometrial hyperplasia
dc.typeMakale
dc.relation.journalMENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
dc.contributor.department, ,
dc.identifier.volume4
dc.identifier.issue1
dc.identifier.startpage24
dc.identifier.endpage27
dc.contributor.firstauthorID118629


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